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HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.
TLDR
While HLA-B*1502 is unlikely to be associated with carbamazepine-related or aromatic anti-epileptic agent-related SJS/TEN in Japanese, HLA*5801 was significantly associated with allopurinol- related S JS/T EN in Japanese.
Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in the clinical trials for novel drug
TLDR
It is proposed that among Japan, Korea, and China, genetic differences are very small for the analyzed common PK-related gene polymorphisms.
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the
TLDR
The functional analysis of four naturally occurring human PXR (hPXR) variants (R98C, R148Q, R381W, and I403V) that have recently been identified suggest that they may influence the expression of drug-metabolizing enzymes and transporters, which are transactivated by P XR.
Haplotype structures of the UGT1A gene complex in a Japanese population
TLDR
Important haplotypes and their linkages were identified among the UGT1A gene blocks (and segments), which should be considered in pharmacogenetic studies.
HLA‐B*1511 is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients
TLDR
The genotyped the HLA‐B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions and suggested that HLA·B*1511, a member of HLA•B75, is a risk factor for carbamazepsine‐induced SJS /TEN in Japanese.
RACIAL VARIABILITY IN HAPLOTYPE FREQUENCIES OF UGT1A1 AND GLUCURONIDATION ACTIVITY OF A NOVEL SINGLE NUCLEOTIDE POLYMORPHISM 686C> T (P229L) FOUND IN AN AFRICAN-AMERICAN
TLDR
Differences in haplotype distribution patterns among the three populations suggest the possibility of ethnic differences in toxicity profiles of drugs detoxicated by UGT1A1, and a novel SNP, 686C>T (P229L), was found in an African-American.
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population
TLDR
Using data from 186 subjects enabled a close linkage to be found between CYP3A4 and CYP2A5 SNPs, especially among the SNPs at c.1026+12 in CYP4 and c.1523 in CYp3A5, which suggested that CYP 3A4and CYP1A5 are within the same gene block.
Bisphenol A induces apoptosis in central neural cells during early development of Xenopus laevis.
TLDR
It is demonstrated that BPA induced marked malformations and specific apoptosis of central nervous system cells during early development of X. laevis embryos, and that these BPA effects appeared to be due to non-estrogenic activities on developmental processes.
Identification of the functional vitamin D response elements in the human MDR1 gene.
TLDR
It is demonstrated that the vitamin D receptor (VDR) induces MDR1 expression in a 1alpha,25-dihydroxyvitamin D(3)-dependent manner and the induction is mediated by VDR/RXRalpha binding to several VDREs located between -7880 and -7810bp.
Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects.
TLDR
The data suggest that HLA-A*02:07 and Hla-B*51:01 are potential biomarkers for zonisamide- and phenobarbital-induced SJS/TEN, respectively, in Japanese individuals.
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