• Publications
  • Influence
Human tumor necrosis factor-alpha mutant RGD-V29 (F4614) shows potent antitumor activity and reduced toxicity against human tumor xenografted nude mice.
TLDR
RGD-V29 appears to be a low-toxicity mutant of rhTNF that shows preferential activity towards tumors, and therefore merits further investigation in pre-clinical and clinical studies. Expand
Overcoming the metastasis-enhancing potential of human tumor necrosis factor alpha by introducing the cell-adhesive Arg-Gly-Asp sequence.
TLDR
A mutein, F4168, of human tumor necrosis factor alpha containing the cell-adhesive Arg-Gly-Asp (RGD) sequence near the N terminus was constructed, indicating that the adhesive nature of the RGD sequence is conferred upon hTNF-alpha. Expand
Novel Mutein of Tumor Necrosis Factor α (F4614) with Reduced Hypotensive Effect
TLDR
Results indicated that F4614 has several advantages as a systemic therapeutic drug in the treatment of cancer, and evidence that the Arg → Val mutation at position 29 is largely responsible for the reduced hypotensive effect is presented. Expand
Antiangiogenic activity of tumor necrosis factor-alpha production regulators derived from thalidomide.
TLDR
Novel tumor necrosis factor-alpha production regulators with a phthalimide skeleton derived from thalidomide are shown to be more potent inhibitors of angiogenesis induced by basic fibroblast growth factor in a murine angiogenic assay. Expand
Preferential Activity of Wild‐type and Mutant Tumor Necrosis Factor‐α against Tumor‐derived Endothelial‐like Cells
TLDR
Tumor‐derived endothelial‐like cells (tEC) are prepared by culturing human umbilical vein endothelial cells (HUVEC) in the presence of HT1080 human fibrosarcoma‐conditioned medium and acquire physiological properties of tumor‐associated vasculature, and may be a useful model system for the study of the mechanisms of TNF antitumor action. Expand
A novel Mutein of TNFα Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine
TLDR
The results suggest that the Arg-Gly-Asp sequence introduced into the TNFα molecule abrogates the side effect of this cytokine such as tissue injury or shock, and that F4168 could be useful for systemic therapy. Expand
Novel muteins of human tumor necrosis factor with potent antitumor activity and less lethal toxicity in mice
TLDR
V29 showed potent anti‐tumor activity in 3 consecutive injection schedules despite the decreases in toxicity compared with rhTNF, suggesting that V29 merits further investigation in pre‐clinical and clinical trials. Expand
Novel mutein of tumor necrosis factor alpha (F4614) with reduced hypotensive effect.
TLDR
Results indicated that F4614 has several advantages as a systemic therapeutic drug in the treatment of cancer, and evidence that the Arg-->Val mutation at position 29 is largely responsible for the reduced hypotensive effect is presented. Expand
A YIGSR-containing novel mutein without the detrimental effect of human TNF-α of enhancing experimental pulmonary metastasis
The injection of B16F10 melanoma cells with recombinant human tumor necrosis factor alpha (TNF-α) into the tail vein of C57BL/6 mice resulted in 2- to 25-fold more metastatic foci in the lungs thanExpand
...
1
2
...