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Polyclonal long-term repopulating stem cell clones in a primate model.
TLDR
This study provides direct molecular evidence for a polyclonal, multilineage, and sustained contribution of individual stem cells to primate hematopoiesis and demonstrates the derivation of circulating peripheral blood cells from individual stem cell clones. Expand
Multicenter Evaluation of the Performance Characteristics of the Bayer VERSANT HCV RNA 3.0 Assay (bDNA)
TLDR
The VERSANT HCV RNA 3.0 Assay (bDNA) (Bayer Diagnostics, Tarrytown, N.Y.) was shown to have excellent reproducibility, linearity, and analytical sensitivity across specimen collection matrices and hepatitis C virus (HCV) genotypes 1 to 6. Expand
Genotyping hepatitis C virus isolates from Spain, Brazil, China, and Macau by a simplified PCR method
TLDR
An improved and simplified method of genotyping was developed for classifying hepatitis C virus isolates into the five common genotypes by PCR with genotype-specific primers deduced from the core gene, eliminating the cross-reaction of the antisense primer with some HCV isolates of genotype I/1a found by the original method. Expand
Multicenter evaluation of the Bayer VERSANT HIV-1 RNA 3.0 assay: analytical and clinical performance.
TLDR
The results of these studies showed that the Bayer Assay has excellent reproducibility, a broad linear range, throughput of 168 patient results per two-plate run in a 22-h period, and few limitations for use, making it an attractive method for general laboratory use of monitoring HIV-1-infected patients. Expand
Chromosomal instability and radiosensitivity in myelodysplastic syndrome cells
TLDR
The data suggest that chromosomal instability and DNA repair defects may be involved in the pathophysiology of disease progression of MDS. Expand
The impact of low-dose busulfan on clonal dynamics in nonhuman primates.
TLDR
The clonal diversity of hematopoiesis was significantly decreased after even a single, clinically well-tolerated dose of busulfan, with slow but almost complete recovery over the next several months, suggesting that true long-term repopulating stem cells were not permanently deleted. Expand
The Krüppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs.
TLDR
It is found that mRNA expression of the HKR1 gene was induced in lung-cancer cell lines by exposure to cisplatin using Northern blot analysis, and that high expression levels in lung cancers were associated with antemortem platinum drug administration. Expand
Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor.
TLDR
It is shown that VEGF also inhibits apoptotic cell death that is induced by exposure to the chemotherapeutic drugs etoposide and doxorubicin and the expression level of MCL1, a member of the BCL2 family, was increased by V EGF. Expand
Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia.
TLDR
The results suggest that retroviral integrations using replication-incompetent vectors, at copy numbers achieved using standard protocols, are unlikely to result in leukemogenesis and that patient- or transgene-specific factors most likely contributed to the occurrence of leukemia in the X-SCID gene therapy trial. Expand
Prevalence of antibody to hepatitis C virus in a blood donor population
TLDR
For blood donors, the anti‐HCV test correlates with the surrogate tests for non‐A, non‐B hepatitis (anti‐HBc and ALT); however, most anti‐ HCV‐reactive units remain undetected by surrogate tests, so that implementation of anti-HCV screening should further reduce the transmission of HCV via transfusion. Expand
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