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Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets
TLDR
It is shown that, by inhibiting hnRNPA2 dimerization, apigenin affects the alternative splicing of key mRNAs, and provides a perspective on how dietary phytochemicals function and what distinguishes their action from pharmaceutical drugs.
Multidrug treatment with nelfinavir and cepharanthine against COVID-19
TLDR
This study identifies a new multidrug combination treatment for COVID-19 that combines the HIV protease inhibitor Nelfinavir and the anti-inflammatory drug Cepharanthine to limit SARS-CoV-2 proliferation.
Identification and Characterization of the Direct Interaction between Methotrexate (MTX) and High-Mobility Group Box 1 (HMGB1) Protein
TLDR
HMGB1 is a direct binding protein ofMTX, and binding of MTX to RAGE-binding region in HMGB1 inhibited the HMGB/RAGE interaction at the molecular and cellular levels.
Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B
TLDR
A chemical biology approach is shown that elucidates a novel mechanism underlying cellular and viral physiology of HCV replication and finds a cellular factor, CAHL, as CsA associated helicase-like protein, which would form trimer complex with CyPB and NS5B ofHCV.
Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin.
TLDR
A T7 phage-based display was described to screen for paclitaxel-binding molecules from a random peptide library using paclitxel-photoimmobilized TentaGel resin and found that two phage clones included the same consensus amino acid sequence (KACGRTRVTS), which is conserved in the zinc finger domain of human NFX1.
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
TLDR
The compounds suppressed cell proliferation and growth in five human cancer cell lines, but had no effect on the viability of normal human cell lines.
Short synthesis of berkeleyamide D and determination of the absolute configuration by the vibrational circular dichroism exciton chirality method.
TLDR
The first synthesis of (±)-berkeleyamide D has been accomplished and the absolute configurations of both enantiomers of ber Berkeleyamide D were determined by the vibrational circular dichroism exciton chirality method.
Novel Terpenoids, Trichoderonic Acids A and B Isolated from Trichoderma virens, Are Selective Inhibitors of Family X DNA Polymerases
TLDR
These compounds selectively and competitively inhibited the activities of mammalian DNA polymerases β, λ and terminal deoxynucleotidyl transferase in family X of pols, and compound 2 was a stronger inhibitor than compound 1 or 3.
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