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Localization and Mechanism of Secretion of B‐Type Natriuretic Peptide in Comparison With Those of A‐Type Natriuretic Peptide in Normal Subjects and Patients With Heart Failure
Examination of the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure concludes that BNP is secreted mainly from the left ventricle in normal adult humans as well as in Patients with left ventricular dysfunction.
Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery.
Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease.
Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease.
T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.
Findings strongly suggest that the T-786-->C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.
Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins
It is reported here that arteries exposed to EC-LDL in vitro show an endothelium-dependent vasoregulatory impairment closely resembling that of atherosclerotic arteries.
Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.
Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.
Findings suggest that the -588T polymorphism of the GCLM gene may suppress G CLM gene induction in response to oxidants and that it is a genetic risk factor for MI.
A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese
The missense Glu298Asp variant in the eNOS gene is found by the analysis of its entire 26 coding regions and is significantly associated with coronary spasm.
Hypochlorous Acid, a Macrophage Product, Induces Endothelial Apoptosis and Tissue Factor Expression: Involvement of Myeloperoxidase-Mediated Oxidant in Plaque Erosion and Thrombogenesis
- S. Sugiyama, K. Kugiyama, M. Aikawa, Shin-ichi Nakamura, H. Ogawa, P. Libby
- Biology, MedicineArteriosclerosis, thrombosis, and vascular…
- 1 July 2004
These results show that MPO-positive macrophage-derived HOCl in the subendothelium of atheromata may participate in ACS by promoting superficial erosion and increasing thrombogenicity.