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Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.
Azole antifungal agents, and especially fluconazole, have been used widely to treat oropharyngeal candidiasis in patients with AIDS. An increasing number of cases of clinical resistance againstExpand
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Detoxification of the Fusarium Mycotoxin Deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana*
Plant pathogenic fungi of the genus Fusarium cause agriculturally important diseases of small grain cereals and maize. Trichothecenes are a class of mycotoxins produced by different Fusarium speciesExpand
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The Pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast
Exposure of Saccharomyces cerevisiae to sorbic acid strongly induces two plasma membrane proteins, one of which is identified in this study as the ATP‐binding cassette (ABC) transporter Pdr12. In theExpand
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Global Gene Deletion Analysis Exploring Yeast Filamentous Growth
Infectious Phenotype The pathogenic yeast Candida albicans needs to adopt a filamentous form to invade tissues. The distantly related yeast species Saccharomyces cerevisiae also takes on aExpand
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Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance.
Saccharomyces cerevisiae was the first eukaryotic organism whose complete genome sequence has been determined, uncovering the existence of numerous genes encoding proteins of the ATP-binding cassetteExpand
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ABC proteins : from bacteria to man
Preface. Introduction. PART 1-PHYLOGENY AND EVOLUTION OF ABC-TRANSPORTERS Phylogenetic and Functional Classification of ABC (ATP-binding cassette) Systems Membrane Topology of the Human ABCExpand
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Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance
Mammalian innate immune cells produce reactive oxygen species (ROS) in the oxidative burst reaction to destroy invading microbial pathogens. Using quantitative real‐time ROS assays, we show here thatExpand
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War1p, a Novel Transcription Factor Controlling Weak Acid Stress Response in Yeast
ABSTRACT The Saccharomyces cerevisiae ATP-binding cassette (ABC) transporter Pdr12p effluxes weak acids such as sorbate and benzoate, thus mediating stress adaptation. In this study, we identify aExpand
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Endoplasmic Reticulum Degradation of a Mutated ATP-binding Cassette Transporter Pdr5 Proceeds in a Concerted Action of Sec61 and the Proteasome*
Degradation of misfolded or tightly regulated proteins in the endoplasmic reticulum (ER) is performed by the cytosolic ubiquitin-proteasome system and therefore requires their prior transport back toExpand
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Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae.
Weak organic acids such as sorbate are potent fungistatic agents used in food preservation, but their intracellular targets are poorly understood. We thus searched for potential target genes andExpand
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