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Endophytic fungi: a source of novel biologically active secondary metabolites * * Paper presented at
TLDR
It is hypothesize that the interaction fungal endophyte-plant host is characterized by a finely tuned equilibrium between fungal virulence and plant defence, and if this balance is disturbed by either a decrease in plant defence or an increase in fungalvirulence, disease develops. Expand
Metabolites from the Endophytic Fungus Nodulisporium sp. from Juniperus cedre
Seven new metabolites, 3-hydroxy-1-(2,6-dihydroxyphenyl)butan-1-one (1), 1-(2-hydroxy-6-methoxyphenyl)butan-1-one (3), 2,3-dihydro-5-methoxy-2-methylchromen-4-one (6), the dimeric naphthalenesExpand
Lapachol: An overview
Lapachol is a naphthoquinone that was first isolated by E. Paterno from Tabebuia avellanedae (Bignoniaceae) in 1882. A wide spectrum of therapeutic activities have been attributed to lapachol or itsExpand
Biologically active secondary metabolites of endophytic Pezicula species
TLDR
Endophytic Pezicula strains were isolated from living branches of ten deciduous and coniferous trees and tested for their fungicidal, algicidal and antibacterial activities and the synthesis of these metabolites in 85 isolates was dependent on conditions of culture and was also found to be taxonomically significant. Expand
The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis
TLDR
Data show that NSAIDs can affect the disposition of methotrexate, possibly increasing the potential for toxicity and necessitating dosage adjustments, however, large inter-subject variability precludes specific dosage recommendations. Expand
Antifungal nortriterpene and triterpene glycosides from the sea cucumber Apostichopus japonicus Selenka.
TLDR
A preliminary structure-activity analysis suggests that the 18(20) lactone group and the Δ(25) terminal double bond may increase the activity and the component of the carbohydrate chain seems play an important role whereas the double bond transformation from Δ(9(11)) to Δ(7) in the aglycone moiety contributes little to the bioactivity. Expand
ANGUCYCLINES : TOTAL SYNTHESES, NEW STRUCTURES, AND BIOSYNTHETIC STUDIES OF AN EMERGING NEW CLASS OF ANTIBIOTICS
General and recent aspects of chemical syntheses on angucyclinones and selected related natural products are summarized here. In the first part of this review on angucyclines, the chemical reactionExpand
Three New Antimicrobial Metabolites from the Endophytic Fungus Phomopsis sp.
Two new chromones, phomochromone A and B (1 and 2), and one new natural cyclopentenone derivative, phomotenone (3), together with six known compounds, phomosines A-D (4-7),Expand
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