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A human gut microbial gene catalogue established by metagenomic sequencing
To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and… Expand
SOAP2: an improved ultrafast tool for short read alignment
SUMMARY SOAP2 is a significantly improved version of the short oligonucleotide alignment program that both reduces computer memory usage and increases alignment speed at an unprecedented rate. Expand
De novo assembly of human genomes with massively parallel short read sequencing.
Next-generation massively parallel DNA sequencing technologies provide ultrahigh throughput at a substantially lower unit data cost; however, the data are very short read length sequences, making de… Expand
SOAP: short oligonucleotide alignment program
SUMMARY We have developed a program SOAP for efficient gapped and ungapped alignment of short oligonucleotides onto reference sequences using the new generation Illumina-Solexa sequencing technology. Expand
A metagenome-wide association study of gut microbiota in type 2 diabetes
Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis… Expand
The genome of the cucumber, Cucumis sativus L.
Cucumber is an economically important crop as well as a model system for sex determination studies and plant vascular biology. Here we report the draft genome sequence of Cucumis sativus var. sativus… Expand
SNP detection for massively parallel whole-genome resequencing.
Next-generation massively parallel sequencing technologies provide ultrahigh throughput at two orders of magnitude lower unit cost than capillary Sanger sequencing technology. One of the key… Expand
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
No Genetic Vertigo Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz). To identify gene regions that might have contributed to high-altitude adaptation in… Expand
Evolution of genes and genomes on the Drosophila phylogeny
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome… Expand
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life.
The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large… Expand