• Publications
  • Influence
Identification and Characterization of CD39/Vascular ATP Diphosphohydrolase*
Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available from various mammalian andExpand
  • 503
  • 25
Loss of ATP Diphosphohydrolase Activity with Endothelial Cell Activation
Quiescent endothelial cells (EC) regulate blood flow and prevent intravascular thrombosis. This latter effect is mediated in a number of ways, including expression by EC of thrombomodulin and heparanExpand
  • 278
  • 11
  • PDF
Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity.
CD39, the mammalian ATP diphosphohydrolase (ATPDase), is thought to contain two transmembrane domains and five "apyrase conserved regions" (ACR) within a large extracellular region. To study theExpand
  • 109
  • 5
Adenovirus-mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis.
We hypothesized that blocking the induction of proinflammatory genes associated with endothelial cell (EC) activation, by inhibiting the transcription factor nuclear factor kappaB (NF-kappaB), wouldExpand
  • 83
  • 3
Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes.
Purinergic signaling may influence hemostasis, inflammatory responses and apoptosis. Therefore, hydrolysis of extracellular ATP and ADP by the ATP diphosphohydrolase (ATPDase) could regulate theseExpand
  • 114
  • 3
  • PDF
Palmitoylation Targets CD39/Endothelial ATP Diphosphohydrolase to Caveolae*
Ectonucleotidases influence purinergic receptor function by the hydrolysis of extracellular nucleotides. CD39 is an integral membrane protein that is a prototype member of the nucleosideExpand
  • 81
  • 3
RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3‐kinase
Platelet activation by different agonists initiates a signalling cascade involving the phosphorylation of several protein kinases, which control key regulatory events. Previously, we demonstratedExpand
  • 27
  • 2
Extracellular ATP and ADP activate transcription factor NF-kappa B and induce endothelial cell apoptosis.
Inflammation within the vasculature is associated with endothelial cell (EC) perturbation, loss of vascular ATP-diphosphohydrolase activity, and platelet microthrombus formation with release of ATPExpand
  • 92
  • 1
Inhibition of cyclooxygenase-2 indirectly potentiates antitumor effects of photodynamic therapy in mice.
PURPOSE The aim of the present study was to potentiate the antitumor effectiveness of photodynamic therapy (PDT). A cDNA microarray analysis was used to evaluate the gene expression pattern afterExpand
  • 56
  • 1
  • PDF
Correction of posttransplant erythrocytosis with enalapril.
Erythrocytosis (i.e., elevation in red cell mass) frequently develops after renal transplantation and is associated with increased risk of thromboembolic incidents and hypertension. Because it hasExpand
  • 36
  • 1