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Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males.
TLDR
Lifestyle intervention aimed at achieving ideal body weight in men with IGT is effective and can be conducted in an outpatient clinic setting, and a linear correlation between the incidence of diabetes and the BMI values was revealed with the exception of the DaQing Study. Expand
Immunogenetic and Clinical Characterization of Slowly Progressive IDDM
TLDR
The results indicate that the clinical subtype with slowly progressive course (slowly progressive IDDM) has distinct findings including late-age onset, high prevalence of islet cell antibodies, preserved β-cell function, and high family history of NIDDM. Expand
A mutation in the beta 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects.
TLDR
The Trp 64 Arg mutation in the beta 3-adrenergic receptor (beta 3AR) gene was investigated in 350 Japanese subjects and may be one of the loci contributing to obesity and hyperinsulinemia/insulin resistance in Japanese subjects. Expand
HbA1c 5·7–6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study
TLDR
The predictive value for progression to diabetes assessed by HbA(1c) 5·7-6·4% was similar to that assessed by impaired fasting glucose alone, suggesting the two tests used together could efficiently target people who are most likely to develop diabetes and allow for early intervention. Expand
Time Course of Islet Cell Antibodies and β-Cell Function in Non-Insulin-Dependent Stage of Type I Diabetes
TLDR
The reversed β-cell function after negative conversion of ICA observed in this study yields a new insight into the natural history of type I diabetes, especially in late-onset cases and suggests that HLA-related genetic predisposition is a prerequisite to the slowly progressive β- cell destruction through pancreatic autoimmunity. Expand
Small Doses of Subcutaneous Insulin as a Strategy for Preventing Slowly Progressive β-Cell Failure in Islet Cell Antibody—Positive Patients With Clinical Features of NIDDM
TLDR
Subcutaneous small doses of insulin, resulting in a high rate of negative conversion of ICA and an improved serum C-peptide response, may be effective in treating ICA+ NIDDM patients who are at high risk for slowly progressive β-cell failure. Expand
Health risks among Japanese men with moderate body mass index
TLDR
Measurement of waist circumference may be a preliminary method for the survey of people at higher risk of lifestyle‐related disorders in Japanese men, especially among those with moderate BMI. Expand
Heterogeneous relationship of early insulin response and fasting insulin level with development of non-insulin-dependent diabetes mellitus in non-diabetic Japanese subjects with or without obesity.
TLDR
It is concluded that most cases of diabetes in Japanese begin with decreased insulin secretion, but a small group of diabetes patients may start with insulin resistance, especially obese subjects. Expand
The Pharmacokinetics of Insulin After Continuous Subcutaneous Infusion or Bolus Subcutaneous Injection in Diabetic Patients
TLDR
The following conclusions can be drawn: (1) the plasma concentration-time profile of insulin after CSII or bolus s.c. insulin administration in the patients with IDDM or NIDDM can be analyzed by pharmacokinetic modeling, and (2) the absorption kinetics of insulin did ot differ significantly between two modes of s. Expand
Risk factors for worsening to diabetes in subjects with impaired glucose tolerance
TLDR
Multivariate analysis indicated that a diminished insulin response and a high maximal body weight index, as well as a high level of fasting and 2-h glucose values at the initial 100-g oral glucose tolerance test were significant independent risk factors for the development of diabetes in Japanese subjects. Expand
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