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AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes.
The appropriate sorting of vesicular cargo, including cell-surface proteins, is critical for many cellular functions. Ubiquitinated cargo is targeted to endosomes and digested by lysosomal enzymes.Expand
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Relationship between recovery of cell surface charge and colony-forming ability following radiation damage in three cell-lines.
SummaryAlterations in the negative surface charge after x-irradiation were investigated by cell electrophoresis in three different radiosensitive cell-lines: Burkitt lymphoma cells P3HR-1Expand
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Role of calcium fluxes in the sustained phase of angiotensin II-mediated aldosterone secretion from adrenal glomerulosa cells.
When angiotensin II stimulates aldosterone secretion, it causes a rapid but transient mobilization of calcium from an intracellular pool and a sustained increase in the influx of calcium in adrenalExpand
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Effects of ANG II and K+ on Ca efflux and aldosterone production in adrenal glomerulosa cells.
A comparison was made of the effects of angiotensin II (ANG II) and K+ on aldosterone secretion and calcium efflux from porcine adrenal glomerulosa cells. In the presence of 1.25 mM Ca2+ in theExpand
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Calcium as intracellular messenger: sensitivity modulation, C-kinase pathway, and sustained cellular response.
A model of information flow in the calcium messenger system is presented. When Ca2+ serves as an intracellular messenger in cells exhibiting a sustained response to an extracellular messenger, thereExpand
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Characterization of hydrolysis and transglycosylation by testicular hyaluronidase using ion-spray mass spectrometry.
Various oligosaccharides from hyaluronic acid, which were fluorescence-labeled and blocked by pyridylamination at the reducing terminal, were incubated as substrates or acceptors with bovineExpand
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Glycine-rich Region of Mitochondrial Processing Peptidase α-Subunit Is Essential for Binding and Cleavage of the Precursor Proteins*
Mitochondrial processing peptidase, a metalloendopeptidase consisting of α- and β-subunits, specifically recognizes a large variety of mitochondrial precursor proteins and cleaves off amino-terminalExpand
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Determination of the Cleavage Site of the Presequence by Mitochondrial Processing Peptidase on the Substrate Binding Scaffold and the Multiple Subsites inside a Molecular Cavity*
Mitochondrial processing peptidase (MPP) recognizes a large variety of basic presequences of mitochondrial preproteins and cleaves the single site, often including arginine, at the −2 position (P2).Expand
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The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways.
Angiotensin II (AII) regulates the secretion of aldosterone from adrenal glomerulosa cells by a calcium-dependent mechanism which involves both the uptake of calcium from the extracellular pool, andExpand
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Intracellular calcium and adenosine 3',5'-cyclic monophosphate as mediators of potassium-induced aldosterone secretion.
We compared the action of K+ on aldosterone secretion from isolated bovine adrenal glomerulosa cells with that of ionophore A23187. Addition of either 50 nM-A23187 or 8 mM-K+ to perifused cellsExpand
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