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Identification of fusion genes in breast cancer by paired-end RNA-sequencing
BackgroundUntil recently, chromosomal translocations and fusion genes have been an underappreciated class of mutations in solid tumors. Next-generation sequencing technologies provide an opportunityExpand
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miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in Primary Breast Tumors
Introduction Few studies have performed expression profiling of both miRNA and mRNA from the same primary breast carcinomas. In this study we present and analyze data derived from expressionExpand
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Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines
Predicting the impact of microRNAs (miRNAs) on target proteins is challenging because of their different regulatory effects at the transcriptional and translational levels. In this study, we appliedExpand
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The order of genetic events associated with colorectal cancer progression inferred from meta‐analysis of copy number changes
To identify chromosomal aberrations that differentiate among the Dukes' stages of colorectal cancer (CRC) as well as those that are responsible for the progression into liver metastases, we performedExpand
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ADAMTS1, CRABP1, and NR3C1 Identified as Epigenetically Deregulated Genes in Colorectal Tumorigenesis
  • G. Lind, K. Kleivi, +4 authors R. Lothe
  • Biology, Medicine
  • Cellular oncology : the official journal of the…
  • 12 December 2006
Background: Gene silencing through CpG island hypermethylation is a major mechanism in cancer development. In the present study, we aimed to identify and validate novel target genes inactivatedExpand
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Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
Ductal carcinoma in situ (DCIS) is a non‐invasive form of breast cancer where cells restricted to the ducts exhibit an atypical phenotype. Some DCIS lesions are believed to rapidly transit toExpand
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Genome signatures of colon carcinoma cell lines.
In cancer biology, cell lines are often used instead of primary tumors because of their widespread availability and close reflection of the in vivo state. Cancer is a genetic disease, commonly causedExpand
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Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
BackgroundDespite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studiedExpand
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Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2.
Aneuploidy is among the most obvious differences between normal and cancer cells. However, mechanisms contributing to development and maintenance of aneuploid cell growth are diverse and incompletelyExpand
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Genome profiling of breast cancer cells selected against in vitro shows copy number changes
About 20% of breast carcinomas show no clonal chromosome abnormalities when analyzed after short‐term culturing. An interesting question is whether this subset of breast carcinomas really isExpand
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