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Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice
TLDR
Brain to serum concentrations of both substances were significantly higher after acute and sub-chronic administration in connection to the expression of P-gp indicated by higher levels in abcb1ab (-/-) mice especially for dehydroaripiprazole. Expand
Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study.
TLDR
Its dissociation from those receptors is very slow, such that in patients with serum aripiprazole concentrations in the range typical for clinical practice, D(2)/D(3) receptors must remain nearly saturated for as long as 1 week after the last dose. Expand
Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects
TLDR
It seems likely that therapeutic drug monitoring can be helpful to improve the antipsychotic drug therapy, as serum levels of aripiprazole and dehydroaripiprazoles were highly variable between individuals and distinct ranges were associated with good therapeutic response and minimal side effects. Expand
Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice
TLDR
P-gp-dependent brain distribution kinetics and behavioral effects of risperidone give evidence that the expression of P-gp has an impact on psychotropic drug actions when treating patients with drugs that are substrates of P,glycoprotein. Expand
Rotarod Impairment: Catalepsy-Like Screening Test for Antipsychotic Side Effects
TLDR
Catalepsy test and rotarod performance test were useful methods to detect side effects of both generation antipsychotics. Expand
Evaluation of two immunoassay procedures for drug testing in hair samples.
TLDR
The test was not useful for a preliminary screening for tetrahydrocannabinol (sensitivity of 65%) and was only useful for morphine and cocaine testing at low recommended new cutoff values (0.1 ng/mg) revealing sensitivities of 94% and 99%, respectively. Expand
In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes
TLDR
Combination of in vitro, and in vivo methods highlights that inhibitory potency did not reflect P-gp related drug disposition, but, when drugs were ranked for inhibitors, this order is reflected in pharmacodynamic changes or vice versa. Expand
An uncommon case of a suicide with inhalation of hydrogen cyanide.
TLDR
This case report of a person who was not familiar with chemicals demonstrates the acquisition of professional information via the internet, enabling a suicide with a complex procedure. Expand
Therapeutic monitoring of aripiprazole by HPLC with column-switching and spectrophotometric detection.
TLDR
Therapeutic drug monitoring (TDM), which is established practice for many antipsychotic drugs, may be helpful for patients treated with aripiprazole, and blood for serum preparation was collected from 27 schizophrenic patients who had been treated with the drug. Expand
Two cases of suicide by asphyxiation due to helium and argon.
TLDR
In absence of analytical data supporting helium exposure, the causes of death in the actual cases were found to be asphyxia and in both cases the manner was suicide. Expand
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