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Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase from Escherichia coli
- P. Brandish, K. Kimura, M. Inukai, R. Southgate, J. Lonsdale, T. Bugg
- Medicine, BiologyAntimicrobial agents and chemotherapy
- 1 July 1996
The antibacterial agents tumicamycin and liposidomycin B are characterized as inhibitors of solubilized Escherichia coli phospho-N-acetylmuramyl-pentapeptide translocase and the results provide insight into the molecular mechanisms of action of these two classes of nucleoside antibiotics.
Glucose dehydrogenase (hexose 6-phosphate dehydrogenase) and the microsomal electron transport system. Evidence supporting their possible functional relationship.
Observations indicate that in microsomes the NADPH generated by glucose dehydrogenase is immediately oxidized by NADPH-cytochrome c reductase, and that glucose dehydrogensase may be functioning to supply NADPH.
Mutational analysis of the Sar1 protein, a small GTPase which is essential for vesicular transport from the endoplasmic reticulum.
A site-directed mutational study was performed to identify the amino acid residues that are essential for the Sar1p function, and the replacement by serine of the only cysteine residue present in Sar1P caused no significant change in the growth phenotype.
Activities of mutant Sar1 proteins in guanine nucleotide binding, GTP hydrolysis, and cell-free transport from the endoplasmic reticulum to the Golgi apparatus.
Five mutant Sar1 proteins are purified using an Escherichia coli expression system and characterized their biochemical properties in detail, finding that three prefer GDP binding to GTP binding and are thus regarded as GDP-form mutants, and one is insensitive to the GTPase-activating protein and is almost fixed in theGTP-bound state.
Inhibition of nuclear factor-κB activation improves the survival of rats with taurocholate pancreatitis
Early blockage of NF-κB activation may be effective in reducing fatal outcome in severe acute pancreatitis, although it did not affect the early increase in serum amylase and histological findings.
Effects of hesperidin on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats.
- Xinhui Wang, J. Hasegawa, +5 authors K. Kimura
- Chemistry, MedicineJournal of pharmacological sciences
Hesperidin may improve hypercholesterolemia and fatty liver by inhibiting both the synthesis and absorption of cholesterol and regulating the expression of mRNA for RBP, C-FABP, and H-F ABP.
Postischemic expression of P-selectin immunoreactivity in rat brain
P-selectin immunoreactivity was not normally present in rat brain sections, however, it was expressed mainly in the post-capillary venules of the cerebral cortex and caudate in the MCA territory with a peak at 8 h-1 day.
Induction of heme oxygenase-1 in the rat brain by kainic acid-mediated excitotoxicity: the dissociation of mRNA and protein expression in hippocampus.
- K. Nakaso, M. Kitayama, +5 authors K. Yamada
- Chemistry, MedicineBiochemical and biophysical research…
- 27 May 1999
The dissociation between HO-1 mRNA and protein level in the hippocampal pyramidal neurons, which is known to be vulnerable against excitotoxicity, is demonstrated and the correlation between this dissociation and the vulnerability of hippocampal Pyramidal neuron is discussed.
Effects of kainate-mediated excitotoxicity on the expression of rat counterparts of A170 and MSP23 stress proteins in the brain.
- K. Nakaso, M. Kitayama, +6 authors K. Yamada
- Biology, MedicineBrain research. Molecular brain research
- 8 June 1999
The results suggest that A170 may play a protective role in the brain under kainate-mediated excitotoxicity, and MSP23 was expressed predominantly in neurons, especially in pyramidal neurons of the cerebrum and cerebellar Purkinje cells, while MSP 23 was expressed in oligodendrocytes.
A change of P-selectin immunoreactivity in rat brain after transient and permanent middle cerebral artery occlusion.
- H. Suzuki, K. Abe, S. Tojo, K. Kimura, M. Mizugaki, Y. Itoyama
- MedicineNeurological research
- 1 July 1998
A different temporal but similar spacial and cellular expression of P-selection immunoreactivity between permanent occlusion and reperfusion of MCA in rat brain is suggested.