• Publications
  • Influence
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.
Cross-linking agents that induce DNA interstrand cross-links (ICL) are widely used in anticancer chemotherapy. Yeast genetic studies show that nucleotide excision repair (NER), Rad6/Rad18-dependentExpand
  • 189
  • 14
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis.
Chicken B lymphocyte precursors and DT40 cells diversify their immunoglobulin-variable (IgV) genes through homologous recombination (HR)-mediated Ig gene conversion. To identify DNA polymerases thatExpand
  • 220
  • 6
Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair.
One of the earliest events in the signal transduction cascade that initiates a DNA damage checkpoint is the phosphorylation on serine 139 of histone H2AX (gammaH2AX) at DNA double-strand breaksExpand
  • 50
  • 6
Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1
Wnt signalling is known to promote G1/S progression through the stimulation of gene expression, but whether this signalling regulates mitotic progression is not clear. Here, the function ofExpand
  • 60
  • 6
Formation of embryogenic cell clumps from carrot epidermal cells is suppressed by 5-azacytidine, a DNA methylation inhibitor.
Using a direct somatic embryogenesis system in carrot, we examined the role of DNA methylation in the change of cellular differentiation state, from somatic to embryogenic. 5-Azacytidine (aza-C), anExpand
  • 59
  • 4
Similar Effects of Brca2 Truncation and Rad51 Paralog Deficiency on Immunoglobulin V Gene Diversification in DT40 Cells Support an Early Role for Rad51 Paralogs in Homologous Recombination
ABSTRACT BRCA2 is a tumor suppressor gene that is linked to hereditary breast and ovarian cancer. Although the Brca2 protein participates in homologous DNA recombination (HR), its precise roleExpand
  • 89
  • 3
Improving expression and solubility of rice proteins produced as fusion proteins in Escherichia coli.
For proteins of higher eukaryotes, such as plants, which have large genomes, recombinant protein expression and purification are often difficult. Expression levels tend to be low and the expressedExpand
  • 55
  • 3
Cooperative Roles of Vertebrate Fbh1 and Blm DNA Helicases in Avoidance of Crossovers during Recombination Initiated by Replication Fork Collapse
ABSTRACT Fbh1 (F-box DNA helicase 1) orthologues are conserved from Schizosaccharomyces pombe to chickens and humans. Here, we report the disruption of the FBH1 gene in DT40 cells. Although the yeastExpand
  • 46
  • 3
Fen-1 Facilitates Homologous Recombination by Removing Divergent Sequences at DNA Break Ends
ABSTRACT Homologous recombination (HR) requires nuclease activities at multiple steps, but the contribution of individual nucleases to the processing of double-strand DNA ends at different stages ofExpand
  • 48
  • 2
Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination.
DNA double-strand breaks (DSB) occur frequently during replication in sister chromatids and are dramatically increased when cells are exposed to chemotherapeutic agents including camptothecin. SuchExpand
  • 23
  • 2