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Aromatization of a bicyclic steroid analog, 3-oxodecalin-4-ene-10-carboxaldehyde, by liver microsomal cytochrome P450 2B4.
3-oxodecalin-4-ene-10-carboxaldehyde was synthesized as a bicyclic analog of the aldehyde that is known to be the terminal intermediate in the enzymatic conversion of androgens to estrogens and the conversion of the bicyclic model compound to HTN was shown to be similar to that of the steroid aromatase reaction.
Abstract 171: Characterizing The Role Of Neutrophils In A Mouse Model Of Fibrodysplasia Ossificans Progressiva
This study evaluates the effects of transdermal DFO on reactive oxygen species and cell death in the context of irradiation (IR) to skin.