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The Evolution of Lipophilin Genes from Invertebrates to Tetrapods: DM-20 Cannot Replace Proteolipid Protein in CNS Myelin
The proteolipid protein (PLP) gene encodes two myelin-specific protein isoforms, DM-20 and PLP, which are members of the highly conserved lipophilin family of transmembrane proteins. While theExpand
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Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli.
BACKGROUND Staphylococcus aureus is a leading cause of superficial and invasive human disease that is often refractory to antimicrobial therapy. Vaccines have the potential to reduce the morbidity,Expand
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Analysis of gastrointestinal physiology using a novel intestinal transit assay in zebrafish.
Gastrointestinal function depends upon coordinated contractions to mix and propel food through the gut. Deregulation of these contractions leads to alterations in the speed of material transitExpand
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Differential effect of poly rI.rC and Newcastle disease virus on the expression of interferon and cellular genes in mouse cells.
The expression of type I murine interferon (MuIFN) genes and several other cellular genes was examined in poly rI.rC induced and Newcastle disease virus (NDV) infected mouse cells. Northern analysisExpand
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Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2.
In this study we describe the generation of a transgenic mouse model with neuronal overexpression of the human cyclooxygenase-2, h(COX)-2, to explore its role in excitotoxicity. We report thatExpand
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Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes.
A BALB/c mouse genomic library was screened with a murine interferon alpha 2 (MuIFN-alpha 2) cDNA coding region fragment. Eight clones were isolated which contain different mouse chromosomal segmentsExpand
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Characterization of a mouse interferon gene locus II. Differential expression of alpha-interferon genes.
A cluster of four MuIFN-alpha genes was recently isolated and characterized (1); one of the genes in this cluster had, in the coding region, an internal deletion of 5 amino acids. BacterialExpand
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Expression of Thy-1/lacZ fusion genes in the CNS of transgenic mice.
Thy-1 is a cell surface glycoprotein of unknown function that is found on nerve cells and mature T-lymphocytes. To study the regulation of Thy-1 gene expression, mouse Thy-1.2 genomic sequences wereExpand
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Characterization of the structure and biological functions of a capsular polysaccharide produced by Staphylococcus saprophyticus.
Staphylococcus saprophyticus is a common cause of uncomplicated urinary tract infections in women. S. saprophyticus strain ATCC 15305 carries two staphylococcal cassette chromosome genetic elements,Expand
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