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Theory of 1/T1 and 1/T2 NMRD profiles of solutions of magnetic nanoparticles
Organically coated iron oxide crystallites with diameters of 5–50 nm (“nanoparticles”) are potential magnetic resonance imaging contrast agents. 1/T1 and 1/T2 of solvent water protons are increasedExpand
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Polymeric gadolinium chelate magnetic resonance imaging contrast agents: design, synthesis, and properties.
We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interest as potential MRI blood pool contrast agents. The polymers were designed so that important physicalExpand
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High relaxivity linear Gd(DTPA)‐polymer conjugates: The role of hydrophobic interactions
A series of linear copolymers of DTPA‐class Gd3+ conjugates, linked by α,ω‐alkyldiamides with a varying number (n) of methylenes separating the amide function, were synthesized. Surprisingly, theirExpand
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Blood-pool contrast agents for MRI: a critical evaluation.
Blood-pool contrast agents in current use in clinical MRI are, in the main, small, highly stable, Gd3+-chelate complexes with a single inner-coordinated water molecule on the metal ion.Expand
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Magnetic field dependence of solvent proton relaxation by solute dysprosium (III) complexes.
RATIONALE AND OBJECTIVES Many magnetic resonance imaging (MRI) agents are Gd(III)-based; its half-filled f-shell has an S-ground state and hence a long electronic relaxation time, leading toExpand
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Determination of the relative amounts of free and complexed manganese ions in aqueous solution by nuclear magnetic resonance.
The ratio of the transverse relaxation rate to the longitudinal relaxation rate of water protons (T1/T2) at 90 MHz can be used to determine the relative amounts of free Mn2+ ions (the hexaquo ion)Expand
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Differentiation of nonmetastatic and metastatic rodent prostate tumors with high spectral and spatial resolution MRI
MR images can be acquired with high spectral and spatial resolution to precisely measure lineshapes of the water and fat resonances in each image voxel. Previous work suggests that theExpand
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Functional and anatomic imaging of tumor vasculature: high-resolution MR spectroscopic imaging combined with a superparamagnetic contrast agent.
The advantages of incorporating spectroscopic information into magnetic resonance imaging (MRI) data sets were demonstrated by Dixon (1) and later by others (2,3). This early work focused on imagingExpand
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Investigation of lanthanide‐based starch particles as a model system for liver contrast agents
Gadolinium and dysprosium diethylenetriamine pentaacetic acid‐labeled starch microparticles (Gd‐DTPA‐SP and Dy‐DTPA‐SP) were investigated as model liver contrast agents. The liver contrast efficacyExpand
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