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Phenylisopropylmethylpropinylamine (E-250), a new spectrum psychic energizer.
Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model.
AIMS Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and effective treatment of AF still remains an unmet medical need. AF is associated with atrial conduction disturbances… Expand
Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3: a pre-clinical pilot study.
AIMS Atrial fibrillation (AF) is linked to cardiomyocyte apoptosis, leading to atrial remodelling and reduction in electrical conduction velocity. We hypothesized that genetic suppression of an… Expand
Indications for predismissal testing with arrhythmia-induction in patients receiving an implantable cardioverter defibrillator
AbstractArrhythmia induction during implantation of cardioverter defibrillators (ICD) is a standard procedure. However, controversy exists regarding the need for routine arrhythmia induction before… Expand
Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels.
- K. Kelemen, C. Kiesecker, +9 authors C. Karle
- Biology, Medicine
- Biochemical and biophysical research…
- 21 December 2007
The catechin EGCG is the main flavonoid compound of green tea and has received enormous pharmacological attention because of its putative beneficial health effects. This study investigated for the… Expand
Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy.
Life-threatening ventricular arrhythmias generally occur in the setting of structural heart disease. Current clinical options for patients at risk for these rhythm disturbances are limited. We… Expand
Tridimensional activation patterns of acquired torsade-de-pointes-tachycardias in dogs with chronic AV-block
Abstract.Background:Dogs with chronic AV block exposed to type-III antiarrhythmic agents develop polymorphic ventricular tachycardias (PVT). Controversy exists regarding PVT mechanism and underlying… Expand
Biological Heart Rate Reduction Through Genetic Suppression of Gαs Protein in the Sinoatrial Node
- P. Lugenbiel, A. Bauer, +4 authors D. Thomas
- Journal of the American Heart Association
- 1 April 2012
Background Elevated heart rate represents an independent risk factor for cardiovascular outcome in patients with heart disease. In the sinoatrial node, rate increase is mediated by β1 adrenoceptor… Expand
Physiological and pharmacological analysis of transmembrane action potentials of human atrial fibers.
Transmembrane action potentials (APs) of electrically paced right-atrial tissue obtained from 38 patients of corrective open-heart surgery were analyzed. Two types of APs could be found. The APs of… Expand