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A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).
TLDR
SX-284 specifically inhibits the acetylcholine release from the vagus nerve, and spontaneous movement of the guinea pig ileum was dose-dependently depressed by SX-284.
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[Pharmacological studies of loperamide, an anti-diarrheal agent. I. Effects on diarrhea induced by castor oil and prostaglandin E. (author's transl)].
TLDR
It is suggested that loperamide has a potent anti-diarrheal activity and specificity to the gastrointestinal tract and inhibits the effect of prostaglandin E1 and ricinoleic acid on the intestinal tract in rats.
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Effects of (+)‐pentazocine and 1,3‐di‐o‐tolylguanidine (DTG), sigma (σ) ligands, on micturition in anaesthetized rats
TLDR
The results indicate that typical σ ligands, such as (+)‐pentazocine and DTG, increase bladder capacity in anaesthetized rats, and the mechanism by which ρ ligands change the urinary storage properties in rats may involve pathways in which the function of Gi/o proteins is necessary.
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Urodynamics in acetone‐induced cystitis of anesthetized rats
TLDR
The results suggest that cystitis models induced by intravesical instillation of 30% acetone may be valuable for evaluating drugs for the treatment of urinary frequency.
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Effects of AH-9700, (+)-pentazocine, DTG and oxybutynin on micturition in anesthetized rats with acetone-induced cystitis.
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A novel class of antiulcer agents. 4-Phenyl-2-(1-piperazinyl)quinolines.
The synthesis of a novel class of antiulcer agents, the substituted 4-phenyl-2-(1-piperazinyl)quinolines, and their pharmacological activities (inhibitory effects on hypothermia induced by reserpine…
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Urodynamics in a rat neurogenic bladder model with a unilateral electrolytic lesion of the basal forebrain
TLDR
The development of a neurogenic bladder model in the rat by an electrolytic unilateral lesion of the right basal forebrain is described, which mimics the clinical situation of increased voiding frequency and decreased micturition threshold pressure.
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Synthesis and antiulcer activity of the metabolites of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AS-2646), a novel gastric antisecretory and antiulcer agent.
The metabolites 3 and 4 of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AS-2646, 1), a candidate as a gastric antisecretory and antiulcer drug, were synthesized to confirm the proposed…
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Analysis of 16,16-dimethylprostaglandin E2-induced diarrhea in cecectomized rats.
TLDR
It is suggested that oral administration of dmPGE2 induces a more pronounced secretory diarrhea in cecectomized rats than in control rats, probably due to the lack of the reservoir function of the cecum in the operated animals.
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Pharmacological actions of AH-9700 on micturition reflex in anesthetized rats.
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