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J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors.
Tetraspanin CD9 Is a “Proteolipid,” and Its Interaction with α3 Integrin in Microdomain Is Promoted by GM3 Ganglioside, Leading to Inhibition of Laminin-5-dependent Cell Motility*
- Y. Kawakami, K. Kawakami, S. Hakomori
- Biology, ChemistryThe Journal of Biological Chemistry
- 13 September 2002
The results suggest that GM3 synthesized under +Gal condition promotes interaction of α3 with CD9, which restricts α3 binding to its antibody, which suggests that CD9 recruits α3 in GEM under + Gal condition, whereby GM3 is present.
Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129.
A potent, long-acting, orally active (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: novel muscarinic M(3) receptor antagonist with high selectivity for M(3) over M(2) receptors.
This compound has excellent oral activity at 4 h after oral dosing, inhibiting methacholine-induced bronchoconstriction in dogs, and may be useful in clinical situations in which M(3) over M(2) selectivity is desirable.
[Clinical evaluation of sulpiride against nausea and vomiting during cancer chemotherapy compared with domperidone--envelope method].
- Y. Sakata, H. Suzuki, Y. Yoshida
- Medicine, PsychologyGan to kagaku ryoho. Cancer & chemotherapy
- 1 July 1986
A comparative controlled study of Sulpiride and Domperidone against nausea and vomiting during cancer chemotherapy, with no statistical difference between them, and no side effects were found in either group.
Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives.
A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase.
Face Selectivity in Diels-Alder Reaction of 4-Substituted Semicyclic Dienes with Dienophiles.
Stereoselective Synthesis of a New Muscarinic M3 Receptor Antagonist, J‐104129.