K. Kawai

Publications189
h-index23
Citations2,024
Highly Influential Citations54
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Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.
In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a… Expand
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Antineoplastic activity of honey in an experimental bladder cancer implantation model: In vivo and in vitro studies
Objectives: The antitumor effect of bee honey against bladder cancer was examined in vitro and in vivo. Methods: Three human bladder cancer cell lines (T24, 253J and RT4) and one murine bladder… Expand
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A Comparison of the Neurotoxic Effects on the Spinal Cord of Tetracaine, Lidocaine, Bupivacaine, and Ropivacaine Administered Intrathecally in Rabbits
We have reported that increased glutamate concentrations in microdialysate of the cerebrospinal fluid (CSF) may be clue phenomena to elucidate mechanisms of neurotoxicity of intrathecal tetracaine.… Expand
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Lower Urinary Tract Dysfunction as Persistent Complication of Radical Hysterectomy
Background This study was performed to evaluate late effects on the lower urinary tract after radical hysterectomy.
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A bladder preservation regimen using intra‐arterial chemotherapy and radiotherapy for invasive bladder cancer: A prospective study
Background : A prospective study was performed to investigate combined treatment with intra‐arterial chemotherapy and radiation therapy for bladder preservation in locally invasive bladder cancer.
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Pharmacological profile of TAN‐452, a novel peripherally acting opioid receptor antagonist for the treatment of opioid‐induced bowel syndromes
Aim: Opioid‐induced bowel syndromes deteriorate patients' quality of life and may lead to nonadherence to opioid schedule and under‐treatment of pain. The objective was to characterize the… Expand
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Bleomycin-induced pulmonary toxicity in chemotherapy for testicular cancer
Bleomycin is an antibiotic agent with antitumour activity, discovered in 1966 by Umezawa et al. Today, bleomycin is commonly used in chemotherapy for various tumour types. In testicular cancer… Expand
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How many uncomplicated male and female overactive bladder patients reveal detrusor overactivity during urodynamic study?
Objective: We retrospectively evaluated the incidence of detrusor overactivity (DO) in uncomplicated overactive bladder syndrome (OAB) patients.
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Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence.
Because there are few efficacious medications for drug dependence, many clinical trials are being conducted in earnest to find such medications. Considerable evidence has shown that opioid kappa… Expand
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Analysis of Intravesical Recurrence After Bladder-preserving Therapy for Muscle-invasive Bladder Cancer.
OBJECTIVE The aim of the present study was to analyze the pattern of recurrences after bladder-preserving therapy for muscle-invasive bladder cancer. METHODS The subjects were 77 patients with… Expand
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