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Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at Senescence*
TLDR
It is shown that senescent fibroblasts, much more than presenescent fibro Blasts, stimulate tumor vascularization in mice and support the idea that senescence cells may facilitate age-associated cancer development by secreting factors that promote malignant progression. Expand
Advanced Atherosclerotic Lesions in the Innominate Artery of the ApoE Knockout Mouse
TLDR
The innominate artery, a small vessel connecting the aortic arch to the right subclavian and right carotid artery, exhibits a highly consistent rate of lesion progression and develops a narrowed vessel characterized by atrophic media and perivascular inflammation. Expand
Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption.
TLDR
These studies show a significant association between the number of estrogen receptors and basal release of EDNO in the aorta of mice, and suggest that decreased vascular estrogen receptor number may represent a novel risk factor for cardiovascular diseases. Expand
Gender difference in endothelial dysfunction in the aorta of spontaneously hypertensive rats.
TLDR
Investigation of endothelium-dependent responses of thoracic aorta isolated from age-matched male and female spontaneously hypertensive rats (SHR) to explore gender differences in endothelial dysfunction suggests that sex steroid hormones may control endothelia-dependent vascular reactivity. Expand
Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve.
TLDR
It is suggested that endogenous eNOS-derived NO exerts direct effects in preserving blood flow, thereby promoting arteriogenesis, angiogenesis and mural cell recruitment to immature angiogenic sprouts. Expand
Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice.
TLDR
The acceleration in lesion size concomitant to the severely impaired NO-mediated responses indicates that lack of endogenous NO is an important progression factor of atherosclerosis in the apoE-KO mouse. Expand
Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice by Inhibiting Apoptosis and Proteolysis
TLDR
It is demonstrated that inhibition of Rho-kinase by fasudil attenuated Ang II–induced AAA through inhibition of both apoptosis and proteolysis pathways. Expand
Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice.
TLDR
Results demonstrate for the first time that aortic stiffness determined by PWV increases in 13-mo-old apoE-KO mice, indicating endothelial dysfunction and elastic destruction in vascular wall caused by atherosclerosis may have contributed. Expand
Differential Effects of Selexipag and Prostacyclin Analogs in Rat Pulmonary Artery
TLDR
It is demonstrated that the relaxant efficacy of the selective IP receptor agonist selexipag and its metabolite ACT-333679 is not modified under conditions associated with PAH, whereas relaxation to treprostinil may be limited in the presence of mediators of disease. Expand
Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E.
TLDR
The results suggest that the therapeutic effects of simvastatin may depend on the presence of a functional apolipoprotein E. Expand
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