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Spectrum of gluten-related disorders: consensus on new nomenclature and classification
This review will summarize the current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications. Expand
The Oslo definitions for coeliac disease and related terms
A multidisciplinary task force of 16 physicians from seven countries used the electronic database PubMed to review the literature for CD-related terms and suggested a definition for each term, followed by feedback through a web survey on definitions and discussions during a meeting in Oslo. Expand
Multiple common variants for celiac disease influencing immune gene expression
Variants from 13 new regions reached genome-wide significance and most contain genes with immune functions, with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection. Expand
Increasing prevalence of coeliac disease over time
- S. Lohi, K. Mustalahti, +8 authors M. Mäki
- Alimentary pharmacology & therapeutics
- 1 November 2007
Background The number of coeliac disease diagnoses has increased in the recent past and according to screening studies, the total prevalence of the disorder is around 1%.
Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology
A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries reviewed the literature on diagnosis and management of adult coeliac disease and the recommendations are presented. Expand
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
It is suggested that INFγ/TNFα and IL-13 have differential effects on CL 2, 3 and 4 in tight junctions, which may lead to increased permeability via different mechanisms. Expand
Endocrinological disorders and celiac disease.
The diagnosis of celiac disease requires endoscopic biopsy, but serological screening with antiendomysial and antitissue transglutaminase antibody assays is an easy method for preliminary case finding. Expand
Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure.
The possible presence of celiac disease should be investigated in patients with severe liver disease, and dietary treatment may prevent progression to hepatic failure, even in cases in which liver transplantation is considered. Expand
Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study.
The diagnostic criteria for celiac disease need re-evaluation: endomysial antibody positivity without atrophy belongs to the spectrum of genetic gluten intolerance, and warrants dietary treatment. Expand
Lower economic status and inferior hygienic environment may protect against celiac disease
- A. Kondrashova, K. Mustalahti, +8 authors the EPIVIR Study Group
- Annals of medicine
- 1 January 2008
The prevalence of transglutaminase antibodies and celiac disease is lower in Russian Karelia than in Finland, which may be associated with a protective environment characterized by inferior prosperity and standard of hygiene in Karelian. Expand