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QuaNCAT: quantitating proteome dynamics in primary cells
Here we demonstrate quantitation of stimuli-induced proteome dynamics in primary cells by combining the power of bio-orthogonal noncanonical amino acid tagging (BONCAT) and stable-isotope labeling of…
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A THEMIS:SHP1 complex promotes T-cell survival
TLDR
The THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T‐cell survival.
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Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip
TLDR
The activation of an SRE luciferase reporter by Tip is reported, the viral oncoprotein essentially contributing to human T-cell transformation by Herpesvirus saimiri, and its role in viral oncogenesis is suggested.
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Species restriction of Herpesvirus saimiri and Herpesvirus ateles: human lymphocyte transformation correlates with distinct signaling properties of viral oncoproteins.
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NF-κB activation by the viral oncoprotein StpC is enhanced by ERK-mediated p52 and RelB upregulation
TLDR
The data suggest that ERK-inducing signaling pathways support NF-κB activation by StpC through an enhanced expression of NF-σκB proteins utilized by the alternative pathway, which is triggered by St pC:TRAF2 complexes.
View on Springer
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