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Sequential treatment of human chronic lymphocytic leukemia with bryostatin 1 followed by 2-chlorodeoxyadenosine: preclinical studies.
- R. Mohammad, K. Katato, +6 authors A. Al-Katib
- Clinical cancer research : an official journal of…
- 1 February 1998
We have previously reported that bryostation 1 (Bryo 1) induces differentiation of chronic lymphocytic leukemia (CLL) in vitro to a hairy cell (HC) stage. This study tests the hypothesis that Bryo… Expand
Potentiation of 2-Chlorodeoxyadenosine Activity by Bryostatin 1 in the Resistant Chronic Lymphocytic Leukemia Cell Line (WSU-CLL): Association with Increased Ratios of dCK/5'-NT and Bax/Bcl-2
- Ramzi M. Mohammad, F. Beck, K. Katato, N. Hamdy, N. Wall, A. Al-katib
- Biology, Medicine
- Biological chemistry
- 1 October 1998
The activities of 2-chlorodeoxyadenosine (2-CdA) metabolizing enzymes, deoxycytidine kinase (dCK) and cytosolic 5'-nucleotidase (5'-NT) were measured in control and bryostatin 1 treated CLL cells… Expand
Establishment of a human B-CLL xenograft model: utility as a preclinical therapeutic model.
Chronic lymphocytic leukemia (CLL), a proliferative disease of mature looking B lymphocytes, is the commonest leukemia in western countries. It remains incurable by available treatment modalities. We… Expand
Secondary acute myelogenous leukemia following treatment with oral etoposide