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A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy
Summary Rats treated with the HIV antiretroviral drug stavudine revealed alterations in complex ethologically relevant behaviours associated with pain and a distinct peripheral nerve neuropathology.Expand
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Identification of a Receptor for Neuropeptide VGF and Its Role in Neuropathic Pain*
Background: VGF is a neuropeptide involved in chronic pain. Results: VGF-derived peptide TLQP-21 activates macrophages. We identified gC1qR as a receptor for TLQP-21. Conclusion: TLQP-21 and gC1qRExpand
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Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterolss⃞ Published, JLR Papers in Press, January 24, 2007.
In humans, the brain accounts for about 20% of the body's free cholesterol, most of which is synthesized de novo in brain. To maintain cholesterol balance throughout life, cholesterol becomesExpand
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Targeted lipidomic analysis of oxysterols in the embryonic central nervous system.
In this study two regions of embryonic (E11) mouse central nervous system (CNS) have been profiled for their unesterified sterol content. Using high-performance liquid chromatography (HPLC)-massExpand
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Potential of sterol analysis by liquid chromatography-tandem mass spectrometry for the prenatal diagnosis of Smith-Lemli-Opitz syndrome.
BACKGROUND Smith-Lemli-Opitz syndrome (SLOS), a severe disorder of cholesterol synthesis, is classically diagnosed prenatally by GC-MS analysis of sterols in amniotic fluid. Considering the currentExpand
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Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.
Liver X receptors (Lxrα and Lxrβ) are ligand-dependent nuclear receptors critical for ventral midbrain neurogenesis in vivo. However, no endogenous midbrain Lxr ligand has so far been identified.Expand
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Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow*
In addition to cholesterol-lowering properties, statins exhibit lipid-independent immunomodulatory, anti-inflammatory actions. However, high concentrations are typically required to induce theseExpand
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Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation.
Oxysterols are present in mammalian brain at ng/g-μg/g levels while cholesterol is present at the mg/g level. This makes oxysterol analysis of brain challenging. In an effort to meet this challengeExpand
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Metabolomics and Metabolite Profiling: Past Heroes and Future Developments
Following the sequencing of the human and other genomes, much research effort is now invested in post-genomic science, particularly in the related disciplines of proteomics and metabolomics. In thisExpand
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Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis.
Disulfide bridging offers a convenient approach to generate site-selective antibody conjugates from native antibodies. To optimise the reagents available to achieve this strategy, we describe hereExpand
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