K. Karakoula

Publications19
h-index5
Citations66
Highly Influential Citations3
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Epigenetic genome-wide analysis identifies BEX1 as a candidate tumour suppressor gene in paediatric intracranial ependymoma.
Promoter hypermethylation and transcriptional silencing is a common epigenetic mechanism of gene inactivation in cancer. To identify targets of epigenetic silencing in paediatric intracranial… Expand
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Effect of Vitamin E on Gene Expression Changes in Diet‐Related Carcinogenesis
Abstract: Colorectal cancer (CRC) is responsible for the second highest associated mortality in Western Europe and the United States. Approximately 95% of CRC is sporadic and believed to involve… Expand
  • 15
Cytogenetic analysis of paediatric astrocytoma using comparative genomic hybridisation and fluorescence in-situ hybridisation
Little is known about the cytogenetic and molecular genetic events that lead to the formation of paediatric astrocytoma. We have analysed 57 paediatric astrocytoma (WHO grades I–IV) using comparative… Expand
  • 15
Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma.
A series of related 2-arylindoles have been evaluated for their anticancer activity against a range of glioblastoma cell lines using a number of different cell-based assays to determine cell… Expand
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Exploiting conformationally restricted N,N′-dimethyl-N,N′-diarylureas as biologically active CC double bond analogues: synthesis and biological evaluation of combretastatin A-4 analogues
The biological efficacy of a number of suitably functionalised conformationally restricted N,N′-dimethyl-N,N′-diarylureas, which occupy a similar 3-dimensional space to combretastatin A-4 (CA4), has… Expand
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FGFR1 Expression and Role in Migration in Low and High Grade Pediatric Gliomas
The heterogeneous and invasive nature of pediatric gliomas poses significant treatment challenges, highlighting the importance of identifying novel chemotherapeutic targets. Recently, recurrent… Expand
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Overexpression of Hexokinase 2 is epigenetically regulated by frequent hypomethylation in glioblastoma multiforme
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EPIGENETIC SILENCING OF GENE EXPRESSION IN PEDIATRIC INTRACRANIAL EPENDYMOMA
LAB-PEDIATRICS LABORATORY RESEARCH
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Abstracts from the 2012 BNOS Conference
INTRODUCTION: Boswellia derivatives possess pro-apoptotic potential towards glioblastoma in vitro and inhibit cell growth. We investigated whether combining boswellic acid with either clomipramine or… Expand