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ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR.
Estimation of estrogenic and anti-estrogenic activities of some phthalate diesters and monoesters by MCF-7 cell proliferation assay in vitro.
- T. Okubo, Toshinari Suzuki, Y. Yokoyama, K. Kano, I. Kano
- Chemistry, BiologyBiological & pharmaceutical bulletin
- 1 August 2003
Estrogenic activities of phthalate di and monoesters were studied by in vitro assay of human breast cancer MCF-7 cell proliferation and some were found to be estrogenic and others were anti-estrogenic in vitro.
Cell death induced by the phenolic antioxidant tert-butylhydroquinone and its metabolite tert-butylquinone in human monocytic leukemia U937 cells.
Chromosomal structure of the halophilic archaebacterium Halobacterium salinarium
- S. Takayanagi, S. Morimura, H. Kusaoke, Y. Yokoyama, K. Kano, M. Shioda
- BiologyJournal of bacteriology
- 1 November 1992
The chromosomal structure of the extremely halophilic archaebacterium Halobacterium Salinarium was examined and it was concluded that the H. salinarium chromosome is composed of regions of protein-free DNA and DNA associated with nucleosome-like structures.
Estimation of Estrogenic and Antiestrogenic Activities of Selected Pesticides by MCF-7 Cell Proliferation Assay
- T. Okubo, Y. Yokoyama, K. Kano, Y. Soya, I. Kano
- Chemistry, BiologyArchives of environmental contamination and…
- 14 June 2004
Estrogenic activities of 20 selected pesticides—which are used for agricultural production as insecticides, fungicides and herbicides—were examined by estrogen receptor (ER)-dependent MCF-7 cell proliferation assay, finding chlordecone and pyridate were much more effective as competitors of estrogen binding to ERα than androgen binding to AR and, conversely, nitrofen was a more effective competitor of androgenbinding to AR.
Polyamine transport and metabolism in mouse mammary gland. General properties and hormonal regulation.
Inhibition of cell proliferation by a unique lysophosphatidic acid, PHYLPA, isolated from Physarum polycephalum: signaling events of antiproliferative action by PHYLPA.
- K. Murakami‐Murofushi, K. Kaji, K. Kano, M. Fukuda, M. Shioda, H. Murofushi
- Biology, ChemistryCell structure and function
- 1 October 1993
PHYLPA elicited an increase in 3',5'-cyclic adenosine monophosphate (cAMP) in a biphasic fashion in fibroblast cells and elicited inositol phosphate accumulation, as well as a transient rise in cytoplasmic free Ca2+ ion.
Lipids in Harderian Glands and Their Significance
The Harderian gland, discovered by Harder (1694), is well developed in rodents, lagomorphs, and cetaceans, and may have been lost in primates, terrestrial carnivores, and some other species.
Structure of the α1 subunit of horse Na,K‐ATPase gene