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Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats.
- H. Tanaka, K. Kannari, T. Maeda, M. Tomiyama, T. Suda, M. Matsunaga
- Biology, ChemistryNeuroreport
- 25 February 1999
It is suggested that serotonergic terminals in the striatum can convert exogenously administered L-DOPA into DA that can be released into the extracellular space.
Activation of 5‐HT1A but not 5‐HT1B receptors attenuates an increase in extracellular dopamine derived from exogenously administered l‐DOPA in the striatum with nigrostriatal denervation
- K. Kannari, Hiroshi Yamato, H. Shen, M. Tomiyama, Toshihiro Suda, M. Matsunaga
- Biology, ChemistryJournal of neurochemistry
- 1 March 2001
The hypothesis that serotonergic neurons are primarily responsible for the storage and release of DA derived from exogenous l‐DOPA in the absence of dopaminergic neurons is supported.
A serotonin 5-HT1A receptor agonist prevents behavioral sensitization to l-DOPA in a rodent model of Parkinson's disease
Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA
[Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease].
- K. Kannari, K. Kurahashi, M. Matsunaga
- Psychology, MedicineNo to shinkei = Brain and nerve
- 1 February 2002
Tandospirone is effective in alleviating L-DOPA-induced dyskinesia in 50% of the patients, however, at the same time 50% patients showed slight worsening of parkinsonian features.
Reuptake of L‐DOPA‐derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine transporter
Evidence is provided that L‐DOPA‐derived DA is taken up by the norepinephrine transporter, instead of the dopamine transporter, in the striatum with dopaminergic denervation, which suggests that the nordicphrine transporter could be a promising target in the treatment for Parkinson's disease.
Rapid induction of serotonergic hyperinnervation in the adult rat striatum with extensive dopaminergic denervation
Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats.
- H. Shen, K. Kannari, Hiroshi Yamato, A. Arai, M. Matsunaga
- Biology, ChemistryThe Tohoku journal of experimental medicine
- 1 March 2003
It is suggested that benserazide reduces the central AADC activity in the striatum of rats with nigrostriatal denervation, which leads to changes in the metabolism of exogenous L-DOPA.
Reuptake of l-DOPA-derived extracellular dopamine in the striatum with dopaminergic denervation via serotonin transporters
Fluoxetine reduces l-DOPA-derived extracellular DA in the 6-OHDA-lesioned rat striatum
- Hiroshi Yamato, K. Kannari, H. Shen, Toshihiro Suda, M. Matsunaga
- Biology, PsychologyNeuroreport
- 8 May 2001
The results suggest that SSRIs may impair motor functions in patients with Parkinson's disease by reducing efflux of exogenous L-DOPA-derived DA.