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Ghrelin is a growth-hormone-releasing acylated peptide from stomach
- M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, K. Kangawa
- Medicine, Biology
- 9 December 1999
The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelIn, a peptide specifically releases GH both in vivo and in vitro. Expand
A role for ghrelin in the central regulation of feeding
It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone. Expand
Ghrelin: structure and function.
The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone, but also by gh Relin derived from the stomach, which plays important roles for maintaining GH release and energy homeostasis in vertebrates. Expand
Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.
- K. Kitamura, K. Kangawa, +4 authors T. Eto
- Biology, Medicine
- Biochemical and biophysical research…
- 30 April 1993
Occurrence of adrenomedullin indicates the possible existence of a novel system for circulation control and suggests that adrenomed Mullin is a new hormone participating in blood pressure control. Expand
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
- Y. Date, Y. Ueta, +6 authors M. Nakazato
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 19 January 1999
The unique neuronal distribution of orexins and their functional activation of neural circuits suggest specific complex roles of the peptides in autonomic and neuroendocrine control. Expand
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
It is shown that LIM-kinase 1 (LIMK-1), a serine/threonine kinase containing LIM and PDZ domains, phosphorylates cofilin at Ser’3, both in vitro and in vivo, which indicates that LIMK- 1 participates in Rac-mediated actin cytoskeletal reorganization, probably by phosphoryLating co Filin. Expand
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.
- Tomomi Shiiya, M. Nakazato, +7 authors S. Matsukura
- The Journal of clinical endocrinology and…
It is demonstrated that nutritional state is a determinant of plasma ghrelin in humans andGhrelin secretion is up-regulated under conditions of negative energy balance and down-regulated in the setting of positive energy balance, suggesting the involvement of gh Relin in the regulation of feeding behavior and energy homeostasis. Expand
A new natriuretic peptide in porcine brain
Atrial natriuretic peptide (ANP), a hormone secreted from mammalian atria, regulates the homoeostatic balance of body fluid and blood pressure13. ANP-like immunoreactivity is also present in the… Expand
Junctophilins: a novel family of junctional membrane complex proteins.
The junctophilins (JPs), a novel conserved family of proteins that are components of the junctional complexes, are identified and suggest that JPs are important components of junctional membrane complexes. Expand
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.
This study indicated that the gastric vagal afferent is the major pathway conveying ghrelin's signals for starvation and GH secretion to the brain. Expand