• Publications
  • Influence
NF-κB Activity Is Required for the Deregulation of c-myc Expression by the Immunoglobulin Heavy Chain Enhancer*
TLDR
Results indicate that the NF-κB/Rel transcription factors play an important role in the deregulation of the translocated c-myc gene in Burkitt's lymphoma and suggest that interference with NF-σB function may represent a new approach to the treatment of Burkitt’s lymphoma.
The EBNA2-related resistance towards alpha interferon (IFN-alpha) in Burkitt's lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3.
TLDR
The data suggest that the EBNA2-related IFN resistance in Burkitt's lymphoma cells acts downstream of the activation of ISGF-3, which previously has been shown to be required and sufficient for transcriptional activation of IFN-induced genes.
Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer
TLDR
Increased expression of MafK and/or decreased expression of YY1 by silencing RNA downregulated endogenous c-myc mRNA levels and increased the sensitivity of the cells to doxorubicin.
The Epstein-Barr virus nuclear antigen 2 (EBNA2), a protein required for B lymphocyte immortalization, induces the synthesis of type I interferon in Burkitt's lymphoma cell lines.
TLDR
EBNA2-dependent transcriptional induction of the IFN-beta promoter occurred in EBV-negative Burkitt's lymphoma cells, indicating that other EBV genes were not required for the induction of IFN -beta synthesis.
Enhanced Apoptosis to Chemotherapeutic Agents Is Dependent on NFκB and Bcl2-Related Proteins but Is Independent of P53 and Bax in Burkitt’s Lymphoma Cells.
TLDR
The results suggest that sensitization of Burkitt’s cells to apoptotic death with chemotherapeutic agents requires interference with NFκB activity and changes in the expression of Bcl2-family members but is independent of p53, which indicates that mutated p53 retains the ability to bind the other proteins but has lost transcriptional function.
Germination-initiating Activities for Bacillus subtilis Spores of Analogues of L-Alanine Derived by Modification at the Amino or Carboxyl Group
TLDR
Overall, it can be deduced that both -NH - and -COO- groups, separated by 1 or 2 interatomic distances, are important for germinant activity.
The Epstein-Barr Virus Nuclear Antigen 2 (EBNA2), a Protein Required for B Lymphocyte Immortalization, Induces the Synthesis of Type I Interferon in Burkitts Lymphoma Cell Lines
TLDR
EBNA2-dependent transcriptional induction of the IFN-β promoter occurred in EBV-negative Burkitt's lymphoma cells, indicating that other EBV genes were not required for the induction of IFn-β synthesis.
Constitutive STAT1 tyrosine phosphorylation in U937 monocytes overexpressing the TYK2 protein tyrosine kinase does not induce gene transcription.
TLDR
The results suggest that in addition to activated TYK2, there is a requirement for additional, IFN-alpha-dependent signals for the phosphorylation of STAT2 and the generation of IFn-stimulated gene factor 3 as well as for the conversion of tyrosine-phosphorylated STAT1 into transcriptionally active IFN -alpha activation factor.
Regulation of L-alanine-initiated germination ofBacillus subtilis spores by alanine racemase
TLDR
Spore alanine racemase converted the germinant actively to the inhibitor and this conversion may regulate germination for survival of the population under unfavorable growth conditions such as high population of spores in limited nutrients, high temperature and high pH.
...
1
2
...