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Studies on the biosynthesis of fosfomycin. 4. The biosynthetic origin of the methyl group of fosfomycin.
By bioconversion experiments using two FM non-producing mutants of Streptomyces wedmorensis, NP-7 and A16, it is shown that the epoxide ring of FM was formed by dehydrogenation of 2-hydroxypropylphosphonic acid (HPP)10'11*.
YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological
Two novel antibiotics were found in the culture broth of Bacillus cereus QN03323 which was isolated from the marine sponge Halichondria japonica and exhibited potent antibacterial activities against staphylococci and enterococci including multiple drug resistant strains.
YM-202204, a new antifungal antibiotic produced by marine fungus Phoma sp.
This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells.
Kalimantacins A, B and C, novel antibiotics from Alcaligenes sp. YL-02632S. I. Taxonomy, fermentation, isolation and biological properties.
The taxonomy of the producing strain, fermentation, isolation and biological activities of kalimantacins are reported and inhibit the growth of Staphylococcus aureus and S. epidermidis including multiple-drug resistant strains.
Studies on the biosynthesis of bialaphos (SF-1293) 12. C-P bond formation mechanism of bialaphos: discovery of a P-methylation enzyme.
An enzymatic activity catalyzing P-methylation of N-acetyldemethylphosphinothricin, a biosynthetic intermediate of the herbicide bialaphos, was detected in a cell extract of Streptomyces
YM-30059, a novel quinolone antibiotic produced by Arthrobacter sp.
The strain was identified as a member of the genus Arthrobacter, and named Arth Robacter sp.
Kalimantacin A, B, and C, novel antibiotics produced by Alcaligenes sp. YL-02632S. II. Physico-chemical properties and structure elucidation.
Kalimantacin A, B and C are new antibiotics produced by Alcaligenes sp. YL-02632S. Their structures were elucidated to be novel long chain structure compounds containing O-carbamoyl, amide and
YM-193221, a novel antifungal antibiotic produced by Pseudallescheria ellipsoidea.
A novel antifungal antibiotic, YM-193221, was found in the culture broth of a fungus, Pseudallescheria ellipsoidea, and exhibited potent antIFungal activity against Candida albicans and also inhibited mannan synthesis in the yeast cell wall.
YM-32890 A and B, new types of macrolide antibiotics produced by Cytophaga sp.
Two new types of macrolide antibiotics, YM-32890 A and B, have been isolated from the fermentation broth of cytophaga sp. YL-02905S. In this paper, the taxonomy of the producing strain, fermentation,