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Hemodynamic and hormonal responses to nicorandil in a canine model of acute ischemic heart failure: a comparison with cromakalim and nitroglycerin.
TLDR
The results suggest that nicorandil produces the reduction of both preload and afterload followed by an improvement of cardiac contractility in this model, and may prove to be useful in the treatment of acute ischemic heart failure.
Effects of KC 399, a novel ATP-sensitive K+ channel opener, on electrical and mechanical responses in dog tracheal smooth muscle.
TLDR
KC 399 inhibited more effectively the tonic response of the contraction than the initial phasic response induced by carbachol, and the relaxation and hyperpolarization induced by KC 399 were antagonized by glibenclamide and in part by charybdotoxin due to depolarization of the membrane.
Hemodynamic effects of a dihydropyridine calcium antagonist, NB-818 (NPK-1886) in anesthetized dogs.
TLDR
NB-818 predominantly increases vertebral blood flow (VBF) with concomitant moderate hypotension, and its action is of significantly slower onset and longer duration than that of nicardipine and nimodipine.
Membrane effects of various drugs on isolated rat hepatocytes and erythrocytes.
TLDR
The results suggest that these membrane effects of various drugs on erythrocytes may be useful for screening for hepatocytotoxicity in vitro.
Effect of a new calcium entry blocker, NB-818, on delayed neuronal death in the ischemic gerbil hippocampus.
TLDR
NB-818 exhibited a protective effect on DND in the hippocampal CA1 subfield after transient forebrain ischemia, and its effect persisted for up to 4 weeks, suggesting that NB-8 18 may be useful for clinical treatment of neurological deficit after an ischemic insult.
In vivo bronchodilator action of a novel K+ channel opener, KC 399, in the guinea pig.
TLDR
It is concluded that KC 399 is an orally active, potent and long lasting bronchodilator.
Effect of KC399, a newly synthesized K+ channel opener, on acetylcholine‐induced electrical and mechanical activities in rabbit tracheal smooth muscle
1 Effects of KC399, an opener of ATP‐sensitive K+ channels were investigated on membrane potential, isometric force and intracellular Ca2+ ([Ca2+]i mobilization induced by acetylcholine (ACh) in
Regional and species differences in glyburide‐sensitive K+ channels in airway smooth muscles as estimated from actions of KC 128 and levcromakalim
TLDR
There are regional and species differences in distribution of K+ channels, and at least two different K+ channel opener‐ and glyburide‐sensitive K+annels are present in the dog airway smooth muscles.
The effect of a novel benzopyran derivative, KC 399, on the isolated guinea-pig trachealis and human bronchi.
TLDR
It is concluded that KC 399 is a potent relaxant of isolated guinea-pig trachealis and human bronchi in vitro and could be due to the opening of glibenclamide-sensitive K+ channels.
Effect of the newly synthetized calcium antagonist isopropyl methyl 2-carbamoyloxymethyl-6-methyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate on cerebral venous outflow in dogs.
TLDR
The effects of intravenous administration of isopropyl methyl 2-carbamoyloxymethyl-6-methyl-4-(2,3-dichlorophenyl)-1,4-dihydroyridi ne- 3,5-dicarboxylate suggest that NB-818 is a potent cerebrovasodilator.
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