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MicroRNA and 3T3-L1 pre-adipocyte differentiation.
Mild down-modulations of the up-regulated miRNAs do not appear to affect 3T3-L1 pre-adipocyte differentiation, and changes in the miRNA expression pattern were observed at day 9, when lipid droplets were visible, but not at days 1, 2, or 5 after the induction of differentiation. Expand
Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat.
Naked siRNA was successfully delivered into the epidermis and concomitantly suppressed the expression of an endogenous immuno-regulatory cytokine in a rat model of atopic dermatitis. Expand
Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue.
Ligand-based targeted delivery is an emerging platform in nanomedicine. We report herein on a peptide modified nanocarrier for a ligand-based targeted delivery system. The liposomal surface of theExpand
Validation of the association between the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a Japanese population.
The hypothesis that ALOX5AP contributes to susceptibility for MI was validated in a Japanese population and multiple logistic analysis indicated that the homozygous genotype of the (CA) haplotype was significantly associated with a reduced risk for MI. Expand
Cold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis.
An overview of previous findings on changes in the expression of genes thought to be related to the activation of thermogenesis in BAT is provided to understand the thermogenic function of BAT systematically. Expand
Polymorphism of CYP11B2 Determines Salt Sensitivity in Japanese
The T(−344)C polymorphism in CYP11B2 appears to affect salt sensitivity in Japanese and to have clinical significance, and a significant interaction was observed in 2063 subjects between urinary sodium excretion and systolic blood pressure. Expand
Comparison of gene expression profiles between white and brown adipose tissues of rat by microarray analysis.
Most of the genes encoding mitochondrial proteins, such as subunits of ATP synthase, cytochrome c oxidase, and NADH dehydrogenase, were highly expressed, reflecting possible differences in the cellular content of mitochondria between BAT and WAT. Expand
Vascular-targeted nanotherapy for obesity: unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery.
The systemic administration of a proapoptotic peptide with the delivery via PTNP significantly reduced the body weight of DIO mice, as evidenced by the targeted ablation of adipose endothelial cells. Expand
Assessment of MEF2A mutations in myocardial infarction in Japanese patients.
MEF2A polymorphism does not contribute appreciably to MI in the Japanese population, and the impact of this mutation does not appear to be great. Expand
Gene expression profile in squamous cell carcinoma of the urinary bladder using complementary deoxyribonucleic acid microarray.
This study monitors the gene expression profiles for bilharzial-related SCC of the bladder to be able to compare its data with transitional cell carcinoma microarray data, and can explain the aggressive behavior of S CC of the urinary bladder. Expand