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Predictive factors of all-trans-retinoic acid related complications during induction therapy for acute promyelocytic leukemia
TLDR
High BMI (>35) in female and treatment without Cytarabine to increase the risk of developing complications with ATRA is found.
Factors associated with severe sepsis: prospective study of 94 neutropenic febrile episodes
TLDR
Factors associated with the occurrence of severe sepsis were hypophosphatemia, heart rate/systolic blood pressure ratio, and non-adapted antibiotherapy at the onset of severe Sepsis, which were not predictive.
Risk factors of septic shock in patients with hematologic malignancies and Pseudomonas infections
TLDR
Multivariate analysis revealed that hypophosphatemia, hypoproteinemia, and high serum lactate are significant factors, independently associated with increased risk of septic shock in patients with hematologic malignancies and Pseudomonas infections.
Treatment of acute promyelocytic leukemia with PETHEMA LPA 99 protocol: a Tunisian single center experience
TLDR
Thirty patients are alive in continuous complete remission; two patients died in CR from septic shock and secondary myelodysplastic syndrome respectively; one patient died 47 months after achieving two relapses.
Evaluation of ovarian reserve before and after chemotherapy.
TLDR
The results showed that the high risk gonadotoxicity protocols were BEACOPP for lymphoma treatment and FEC + TXT for breast cancer treatment, however, studies with a larger sample and more time extended monitoring are necessary for a better gonadOToxicity understanding of the cancer treatments available today.
ATRA and anthracycline-based chemotherapy in the treatment of childhood acute promyelocytic leukemia (APL): A 10-year experience in Tunisia
TLDR
It is suggested that, even in the absence of optimal socio-economic condition, ATRA combined with anthracycline-based chemotherapy gives adequate results in childhood APL, as in adults.
Transfusion-related acute lung injury (TRALI) during remission induction course of acute myeloid leukemia: a possible role for all-transretinoic-acid (ATRA)?
TLDR
A case of TRALI occurring during remission induction course of acute myeloid leukemia in a 27-year-old woman who received All-transretinoic-acid (ATRA) is reported, and it is postulate that ATRA may have played a role in this life-threatening complication by priming neutrophil and enhancing their adherence and their activation in the pulmonary endothelium.
Primary Adrenal Lymphoma
TLDR
A 56-year-old patient suffering from B symptoms was diagnosed with diffuse large B-cell lymphoma of the adrenal gland and treated by immunochemotherapy with a complete response before autologous stem cell transplantation.
[Pseudotumor cerebri with all-trans retinoic acid. A case report].
TLDR
A case of an adult with APL who developed PC during induction therapy with ATRA-PC was managed with repeated lumbar punctures and corticotherapy.
[Therapeutic results with apl 93 protocol in acute promyelocytic leukemia (34 cases)].
TLDR
The results are acceptable and can be improved with reduction of failure due to toxic death, probably with omission of cytarabine from induction and consolidation adapted by the Spanish PETHEMA Group.
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