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The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.
We used mice deficient in each of the eight types and subtypes of prostanoid receptors and examined the roles of prostanoids in dextran sodium sulfate-induced (DSS-induced) colitis. Among theExpand
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Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells.
The factors regulating dendritic cell (DC) development and homeostasis are incompletely understood. Here, we demonstrate that DCs express the lymphotoxin (LT)-beta receptor (LT beta R) and that inExpand
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Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
Antigen-specific immune responses in the skin are initiated by antigen uptake into Langerhans cells and the subsequent migration of these cells to draining lymph nodes. Although prostaglandin E2Expand
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Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking
Immunosurveillance requires the coordinated regulation of chemokines and adhesion molecules to guide immune cell migration. However, the critical molecule for governing the high traffickingExpand
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CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.
CCR7 is regarded as an essential chemokine receptor for cutaneous dendritic cell (DC) migration into the regional lymph nodes. However, complete migratory inhibition cannot be obtained inExpand
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Prostaglandin D2 as a mediator of allergic asthma.
Allergic asthma is caused by the aberrant expansion in the lung of T helper cells that produce type 2 (TH2) cytokines and is characterized by infiltration of eosinophils and bronchialExpand
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Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice.
Tregs play an important role in protecting the skin from autoimmune attack. However, the extent of Treg trafficking between the skin and draining lymph nodes (DLNs) is unknown. We set out toExpand
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Requirement of Interaction between Mast Cells and Skin Dendritic Cells to Establish Contact Hypersensitivity
The role of mast cells (MCs) in contact hypersensitivity (CHS) remains controversial. This is due in part to the use of the MC-deficient Kit W/Wv mouse model, since Kit W/Wv mice congenitally lackExpand
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Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis.
Allergic contact dermatitis (ACD) is one of the most common skin diseases, consisting of sensitization and elicitation phases. With the advancement of technology and the discovery of new types ofExpand
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Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations
Melanoma, a skin cancer associated with high mortality rates, is highly radio- and chemotherapy resistant but can also be very immunogenic. These circumstances have led to a recent surge in researchExpand
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