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Comprehensive Characterization of Cancer Driver Genes and Mutations
Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on largeExpand
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma.
Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomasExpand
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterationsExpand
Novel mutations of the MET proto-oncogene in papillary renal carcinomas
Hereditary papillary renal carcinoma (HPRC) is characterized by multiple, bilateral papillary renal carcinomas. Previously, we demonstrated missense mutations in the tyrosine kinase domain of the METExpand
Primary Thyroid-like Follicular Carcinoma of the Kidney: Report of 6 Cases of a Histologically Distinctive Adult Renal Epithelial Neoplasm
Thyroidization of kidney reminiscent of thyroid follicles with accumulation of inspissated colloid-like material in renal tubules is a hallmark of chronic pyelonephritis. We identified 6 tumors inExpand
Pathogenic Germline Variants in 10,389 Adult Cancers
We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-oneExpand
Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma
PurposeMicroRNAs (miRNAs) play an important role as regulators of gene expression in tumourigenesis by controlling many biological processes in growth, development, differentiation and apoptosis.Expand
Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger
Urothelial neoplasms in patients 19 years of age or younger are rare, and the data regarding clinical outcome are conflicting. Molecular data are not available. Urothelial tumours from 14 patientsExpand
Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma--a multicentre study.
AIM OF THE STUDY Papillary renal cell carcinoma (pRCC) is the second most common subtype of RCC after the conventional clear cell type (cRCC). However, its characteristics and prognosis have beenExpand
Clinicopathological features and prognosis of synchronous bilateral renal cell carcinoma: an international multicentre experience
An interesting group of papers in this section is headed by two papers on synchronous bilateral renal tumours, one from an international group of authors and one from Germany. The large series ofExpand