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Human bone marrow-derived clonal mesenchymal stem cells inhibit inflammation and reduce acute pancreatitis in rats.

Human bone marrow-derived clonal MSCs underwent self-renewal and had multipotent differentiation capacities and immunoregulatory functions and might be developed as a cell therapy for pancreatitis.
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Melatonin downregulates nuclear erythroid 2‐related factor 2 and nuclear factor‐kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model

Melatonin increases antioxidant enzymes and NRF2 expression in parallel with the decrease of inflammatory mediators in DMN‐induced liver injury, suggesting that melatonin may play a role of antioxidant defense via the Nrf2 pathway, by reducing inflammation by NF‐κB inhibition.
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Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against Oxidative Stress

Results suggest that fucoidan had an anti-fibrotic effect, which was exerted by inhibiting the TGF-β/Smad pathway, as well as anti-oxidative and anti-inflammatory effects.
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The protective effect of resveratrol on dimethylnitrosamine-induced liver fibrosis in rats

The results suggest that resveratrol could be used to treat liver injury and fibrosis and be useful in preventing the development of liver Fibrosis and cirrhosis.
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Melatonin ameliorates cerulein‐induced pancreatitis by the modulation of nuclear erythroid 2‐related factor 2 and nuclear factor‐kappaB in rats

It is proposed that melatonin may play an important role in oxidative stress via the Nrf2 pathway in parallel with reduction of inflammation by NF‐κB inhibition in cerulein‐induced AP.
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Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells.

The results suggest that amygdalin have an anticancer effect via downregulation of cell cycle-related genes in SNU-C4 human colon cancer cells, and might be used for therapeutic anticancer drug.
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Sensitization of TRAIL-Induced Cell Death by 20(S)-Ginsenoside Rg3 via CHOP-Mediated DR5 Upregulation in Human Hepatocellular Carcinoma Cells

Rg3 is well tolerated and enhances the therapeutic efficacy of TRAIL in mouse xenograft models, suggesting that chemosensitization also occurs in vivo, and supports the further development of Rg3 as a chemosensinger in combined therapy with TRAIL.
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Fluoxetine increases the nitric oxide production via nuclear factor kappa B-mediated pathway in BV2 murine microglial cells

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Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis

Human bone marrow-derived clonal mesenchymal stem cells, isolated from human bone marrow aspirate according to the newly established isolation protocol, have potential therapeutic effects in SAP and could effectively relieve injury of pancreatitis as a promising therapeutics.
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SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells.

SB365 significantly inhibited tumor growth through the induction of apoptosis and inhibition of angiogenesis with strong anticancer activity, and is a good candidate as a natural product for use in the treatment of pancreatic cancer.
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