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Recognition of the fetal alcohol syndrome in early infancy.
TLDR
The first necropsy performed on a patient with fetal alcohol syndrome disclosed serious dysmorphogenesis of the brain, which may be responsible for some of the functional abnormalities and the joint malposition seen in this syndrome. Expand
Epidemiology of fetal alcohol syndrome in a South African community in the Western Cape Province.
TLDR
Fetal alcohol syndrome initiatives that incorporate innovative sampling and active case ascertainment methods can be used to obtain timely and accurate data among developing populations. Expand
Birth outcomes in pregnant women taking fluoxetine.
TLDR
Women who take fluoxetine during pregnancy do not have an increased risk of spontaneous pregnancy loss or major fetal anomalies, but women who take the drug in the third trimester are at increased risk for perinatal complications. Expand
Pattern of malformation in offspring of chronic alcoholic mothers.
TLDR
The similarity in pattern of malformation noted among 8 unrelated children born to mothers who were chronic alcoholics suggests a singular mode of etiology related to an as yet unknown effect of maternal alcoholism. Expand
The fetal alcohol syndrome.
TLDR
The frequency (43%) of adverse outcome of pregnancy for chronic alcoholic women suggests that serious consideration be given to early termination of pregnancy in severely Chronic alcoholic women. Expand
The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly.
TLDR
It is suggested that the interactions of multiple gene products and/or environmental elements may determine the final phenotypic outcome for a given individual and that variations among these factors may cause the wide variability in the clinical features seen in HPE. Expand
Isolated hemihyperplasia (hemihypertrophy): report of a prospective multicenter study of the incidence of neoplasia and review.
TLDR
Results of a prospective multicenter clinical study of the incidence and nature of neoplasia in children evaluated because of isolated hemihyperplasia support a tumor surveillance protocol for children with IHH similar to that performed in other syndromes associated with overgrowth. Expand
Abnormalities of the corpus callosum in children prenatally exposed to alcohol.
TLDR
The results suggest that prenatal exposure to high levels of alcohol is associated with abnormalities of the corpus callosum, and verify callosal agenesis in children with FAS, which previously had only been noted in autopsy reports. Expand
A decrease in the size of the basal ganglia in children with fetal alcohol syndrome.
TLDR
Volumetric analyses demonstrated significant reductions in the cerebral vault, basal ganglia, and diencephalon in the children with fetal alcohol syndrome, compared with control children, which may relate to behavioral findings in both humans and animals exposed to alcohol prenatally. Expand
Central nervous system anomalies associated with meningomyelocele, hydrocephalus, and the Arnold-Chiari malformation: reappraisal of theories regarding the pathogenesis of posterior neural tube
TLDR
The frequency and pattern of brain malformations associated with neural tube defects of some children with meningomyelocele suggest that such mal Formations may seriously affect intellectual outcome. Expand
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