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Advances in metal-induced oxidative stress and human disease.
Detailed studies in the past two decades have shown that redox active metals like iron (Fe), copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions and possess theExpand
Metals, oxidative stress and neurodegenerative disorders
The neurodegenerative diseases, Alzheimer’s disease (AD) and Parkinson’s disease (PD), are age-related disorders characterized by the deposition of abnormal forms of specific proteins in the brain.Expand
Arsenic: toxicity, oxidative stress and human disease
Arsenic (As) is a toxic metalloid element that is present in air, water and soil. Inorganic arsenic tends to be more toxic than organic arsenic. Examples of methylated organic arsenicals includeExpand
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological mechanisms, (ii) an inverse correlation between their incidences, and (iii) oxidative stress being a commonExpand
Importance of iron chelation in free radical-induced oxidative stress and human disease.
Iron is a redox active metal involved in the oxidation-reduction reactions and regulation of cell growth and differentiation. Iron is an integral part of many proteins and enzymes that maintainsExpand
Redox- and non-redox-metal-induced formation of free radicals and their role in human disease
Abstract Transition metal ions are key elements of various biological processes ranging from oxygen formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict limitsExpand
Redox active metal-induced oxidative stress in biological systems
A number of studies performed on biological systems have shown that redox-active metals such as iron and copper as well as other transition metals can undergo redox cycling reactions and produceExpand
Health protective effects of carotenoids and their interactions with other biological antioxidants.
  • K. Jomová, M. Valko
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 1 December 2013
Carotenoids are natural pigments attracting attention of physicists, chemists and biologists due to their multiple functions in the nature. While carotenoids have unusually high extinctionExpand
Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.
Alzheimer's disease is a multifactorial disease that is characterized mainly by Amyloid-β (A-β) deposits, cholinergic deficit and extensive metal (copper, iron)-induced oxidative stress. In this workExpand
FTIR spectroscopy study of polyamide-6 irradiated by electron and proton beams
Polyamide-6 (PA-6) irradiated by a 500 kGy electron beam (EB) dose or by 500 and 1000 kGy proton beam (PB) doses was examined by FTIR spectroscopy, crosslinked portion determination, DSC and tensileExpand
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