K. J. Chang

Publications117
h-index48
Citations8,637
Highly Influential Citations113
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Localization of enkephalin‐like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus
The distribution of enkephalin‐like immunoreactivity in the hippocampal formation of the rat was analyzed. Two specific projection systems are described. The first emerges from the hilus of the… Expand
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Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.
DNA topoisomerase II from Drosophila was phosphorylated effectively by protein kinase C. With a Km of about 100 nM, the reaction was rapid, occurring at 4 degrees C as well as at 30 degrees C and… Expand
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Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.
A systemically active, nonpeptidic delta receptor-selective agonist, (+-)-4-((alpha-R*)-alpha-((2S*,5R*)-4-allyl-2,5-dimethyl-1-piperazinyl) -3- hydroxybenzyl)-N,N-diethylbenzamide (BW373U86),… Expand
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Immunohistochemical localization of enkephalin in rat brain and spinal cord
The distribution of immunoreactive enkephalin in rat brain and spinal cord was studied by immunoperoxidase staining using antiserum to leucine‐enkephalin ([Leu5]‐enkephalin) or methionine‐enkephalin… Expand
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A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86.
Four different opioid receptor binding assays and three different isolated tissue studies were used to screen for delta receptor-selective nonpeptidic compounds.… Expand
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Behavioral effects of the systemically active delta opioid agonist BW373U86 in rhesus monkeys.
The behavioral effects of (+-)-4-((alpha R*)-alpha-((2S*,5R*)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- hydroxybenzyl)-N,N-diethylbenzamide dihydrochloride (BW373U86), a nonpeptidic, systemically… Expand
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Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.
In rat brain membrane preparations, the parenterally and orally active peptide, [D-Ala2, MePhe4, Met(O)5-ol]-enkephalin, binds to morphine receptor sites ([3H]naloxone or [3H]dihydromorphine binding… Expand
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The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
The mitogen-activated protein (MAP) kinase of Chinese hamster ovary cells (CHO mu66 cell line) transfected to express mu-opioid receptors was markedly activated by mu agonists. The rank order of… Expand
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Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.
Several opioid agonists were evaluated in pigeons trained to discriminate i.m. injections of sterile water from either the mu agonist morphine (5.6 mg/kg), the kappa agonist bremazocine (0.032mg/kg)… Expand
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Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines.
Opiate-like materials, as measured by the radioreceptor assay, were found in the adrenal gland of 7 mammalian species including man. The opiate-like materials are confined to the adrenal medulla, and… Expand
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