Share This Author
Parathyroid Hormone (PTH)/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH*
Data indicate that PPR signaling in osteocytes is required for bone remodeling, and receptor signaling in boneocytes is needed for anabolic and catabolic skeletal responses.
Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts
The hypothesis that intermittent PTH treatment can increase osteoblast number by converting lining cells to mature osteoblasts in vivo is supported.
The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro*
Targeted osteocyte therapies could hold promise as novel osteoporosis and disuse-induced bone loss treatments by directly modulating the mechanosensing cells in bone.
Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses.
PTH was unable to suppress Sost and sclerostin expression in the Ocy-PPR(cKO) animals, suggesting an important role of PTH signaling in osteocytes for proper bone remodeling and calcium homeostasis.
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.
Osteocytes, the most abundant yet least understood cells in bone, are thought to initiate adaptive bone remodeling responses via osteoblasts and osteoclasts, and it is reported that these cells regulate hematopoiesis, constraining myelopoiedis through a Gsα-mediated mechanism that affects G-CSF production.
Chronic hyperoxia alters the early and late phases of the hypoxic ventilatory response in neonatal rats
It appears that short exposures to chronic hyperoxia initially enhance the HVR but that this is gradually overcome by impaired carotid body function.
Small Animal Model for Investigation of Subarachnoid Hemorrhage and Cerebral Vasospasm
The suitability of the rat as an animal model for further investigation of subarachnoid hemorrhage is discussed and it is indicated that most of the hemorrhage was resorbed within 3 days, an observation confirmed microscopically by the amount of red blood cells in the subarACHnoid space.
Synthesis of phosphatidylethanol--a potential marker for adult males at risk for alcoholism.
- G. Mueller, M. Fleming, M. Lemahieu, G. S. Lybrand, K. J. Barry
- Medicine, ChemistryProceedings of the National Academy of Sciences…
- 1 December 1988
A pilot study of phosphatidylethanol synthesis in lymphocytes of adult males who have both an alcohol dependency and a family history of alcoholism has revealed that the average potential for phosphatIDylethanols synthesis in this population is significantly elevated over that of control subjects.
Radiofrequency balloon angioplasty. Rationale and proof of principle.
Radiofrequency (RF) current as a source of thermal energy may be useful in combination with balloon angioplasty to reduce PARS and establish the feasibility of RF-mediated vascular tissue welding.
The effect of radiofrequency-generated thermal energy on the mechanical and histologic characteristics of the arterial wall in vivo: implications for radiofrequency angioplasty.