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Parathyroid Hormone (PTH)/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH*
TLDR
Data indicate that PPR signaling in osteocytes is required for bone remodeling, and receptor signaling in boneocytes is needed for anabolic and catabolic skeletal responses. Expand
The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro*
TLDR
Targeted osteocyte therapies could hold promise as novel osteoporosis and disuse-induced bone loss treatments by directly modulating the mechanosensing cells in bone. Expand
Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts
TLDR
The hypothesis that intermittent PTH treatment can increase osteoblast number by converting lining cells to mature osteoblasts in vivo is supported. Expand
Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses.
TLDR
PTH was unable to suppress Sost and sclerostin expression in the Ocy-PPR(cKO) animals, suggesting an important role of PTH signaling in osteocytes for proper bone remodeling and calcium homeostasis. Expand
Small Animal Model for Investigation of Subarachnoid Hemorrhage and Cerebral Vasospasm
TLDR
The suitability of the rat as an animal model for further investigation of subarachnoid hemorrhage is discussed and it is indicated that most of the hemorrhage was resorbed within 3 days, an observation confirmed microscopically by the amount of red blood cells in the subarACHnoid space. Expand
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.
TLDR
Osteocytes, the most abundant yet least understood cells in bone, are thought to initiate adaptive bone remodeling responses via osteoblasts and osteoclasts, and it is reported that these cells regulate hematopoiesis, constraining myelopoiedis through a Gsα-mediated mechanism that affects G-CSF production. Expand
Radiofrequency balloon angioplasty. Rationale and proof of principle.
TLDR
Radiofrequency (RF) current as a source of thermal energy may be useful in combination with balloon angioplasty to reduce PARS and establish the feasibility of RF-mediated vascular tissue welding. Expand
Chronic hyperoxia alters the early and late phases of the hypoxic ventilatory response in neonatal rats.
TLDR
A complex interaction between inhibitory and excitatory effects of hyperoxia on the developing respiratory control system is suggested and it is suggested thathyperoxia also induces plasticity within the central nervous system. Expand
The effect of radiofrequency-generated thermal energy on the mechanical and histologic characteristics of the arterial wall in vivo: implications for radiofrequency angioplasty.
TLDR
Results of these preliminary experiments suggest that balloon angioplasty with adjunctive RF thermal energy may have benefits in reducing the factors causing acute failure of conventional percutaneous transluminal balloon angyplasty. Expand
Variation of the neurofilament medium KSP repeat sub-domain across mammalian species: implications for altering axonal structure
TLDR
It is hypothesize that variations in the number of KSP repeats within neurofilament medium carboxy terminal tail may have contributed to an increase in axonal caliber, increasing nerve conduction velocity as larger mammals evolved. Expand
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