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Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase.
Despite numerous discoveries from genetically engineered mice, relatively few have been translated to the bedside, mainly because it is difficult to translate from genes to drugs. This investigationExpand
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Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload.
Adenylyl cyclase (AC) type 5 (AC5) and AC type 6 (AC6) are the two major AC isoforms in the heart. Cardiac overexpression of AC6 has been shown to be protective in response to several interventions.Expand
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A Possible Relationship of Nocturnal Blood Pressure Variability with Coronary Artery Disease in Diabetic Nephropathy: LB40
Evidence suggests a relationship between short-term blood pressure (BP) variability and cardiovascular target-organ damage. Although a blunted nocturnal decrease in BP and reduced heart rateExpand
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Genetic manipulation and functional analysis of cAMP signalling in cardiac muscle: implications for a new target of pharmacotherapy.
Adenylate cyclase is a membrane-bound enzyme that catalyses the conversion of ATP into cAMP upon activation of cell-surface G-protein-coupled receptors, such as beta-adrenergic receptors, andExpand
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Abstract 5936: Inhibition of Type 5 Adenylyl Cyclase Rescues Cardiomyopathy Induced by Overexpressed beta2-Adrenergic Receptors in the Heart
Chronic beta-adrenergic receptor (beta-AR) stimulation is deleterious and is involved in the pathogenesis of heart failure (HF). Transgenic (Tg) mice, where beta-AR signaling is chronically enhance...
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Abstract 19060: An Anti-Viral Drug with Properties of Selective Inhibition of Adenylyl Cyclase Type 5 Reduces Infarct Size More when Delivered after than Before Reperfusion
There are at least two reasons why very few of the discoveries from genetically engineered mice have been translated to the clinics: 1.Most therapy requires delivery of a drug, since it is difficultExpand
Abstract #2221: Epac enhances melanoma cell migration through tubulin polymerization
Background: Melanoma has a poor prognosis due to its strong metastatic ability. We recently found that Epac, a newly-found target protein of cAMP, enhances melanoma cell migration, which is a pivotalExpand