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Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.
TLDR
Investigation of the cellular and molecular mechanisms underlying acquired resistance to Haemaphysalis longicornis ticks in mice found that antibodies were required, as was IgFc receptor expression on basophils but not on mast cells, and that basophil infiltration to acquired tick resistance was required. Expand
Basophils are essential initiators of a novel type of chronic allergic inflammation.
TLDR
A mAb that reacted with mouse basophils and depleted them when administered in vivo completely abolished the development of IgE-mediated chronic allergic dermatitis that is characterized by massive eosinophil infiltration, even though basophil accounted for only approximately 2% of the infiltrates. Expand
Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness
TLDR
An indispensable role for MCs as effector cells in airway hyperresponsiveness (AHR) is demonstrated, using newly established Mas-TRECK and Bas- tRECK models. Expand
Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections
TLDR
It is demonstrated that mast cells play a critical role for activation of ILC2 responsible for parasite expulsion in the early phase, and mast cells are supposed to contribute to protection against helminthic infection in the later phase. Expand
Intranasal Immunization with Recombinant Ascaris suum14-Kilodalton Antigen Coupled with Cholera Toxin B Subunit Induces Protective Immunity to A. suum Infection in Mice
  • N. Tsuji, Kayo Suzuki, +4 authors T. Isobe
  • Medicine, Biology
  • Infection and Immunity
  • 1 December 2001
TLDR
The immunization trial results in laboratory animals suggest the possibility of developing a mucosal vaccine for parasitic diseases caused by ascarid nematodes, and As14 is the first protective antigen against A. suum infection to be identified. Expand
Molecular Phylogeny of the Subfamily Gerbillinae (Muridae, Rodentia) with Emphasis on Species Living in the Xinjiang-Uygur Autonomous Region of China and Based on the Mitochondrial Cytochrome b and
TLDR
The phylogenetic analyses suggest that the genus Meriones is not monophyletic and place M. tamaricinus as the sister taxon to a clade comprising Brachiones, Psammomys, Rhombomys and the other Merione species. Expand
Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan.
TLDR
Results indicate that the α-Gal epitope is present not only in Amblyomma or Ixodes, but also in Haemaphysalis, the vector for Japanese spotted fever. Expand
Concurrent infection with Heligmosomoides polygyrus suppresses anti‐Plasmodium yoelii protection partially by induction of CD4+CD25+Foxp3+ Treg in mice
TLDR
It is suggested that intestinal nematodes moderate host immune responses during acute malaria infection by aggressive activation of Treg, which is consistent with previous reports on co‐infection with Plasmodium yoelii 17XNL. Expand
Feline interferon-ω treatment on canine parvovirus infection
TLDR
Recombinant feline interferon-ω preparation (rFeIFN-ω) showed good clinical efficacy on canine parvovirus infection both in an experimental trial with beagles, and in field trials. Expand
Costimulator B7-DC Attenuates Strong Th2 Responses Induced by Nippostrongylus brasiliensis
TLDR
The results show that B7-DC plays an important role in bolstering a robust Th1 response that is required for effective antiviral and anticancer immunity, even under a strong Th2-polarizing environment induced by N. brasiliensis infection. Expand
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