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Inhibitors of Intracellular Signaling Pathways that Lead to Stimulated Epidermal Pigmentation: Perspective of Anti-Pigmenting Agents
Extracts of the herbs Withania somnifera and Melia toosendan and the natural chemicals Withaferin A and Astaxanthin are new candidates for potent anti-pigmenting substances that avoid the risk of hypopigmentation. Expand
Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE‐high extrinsic and IgE‐normal intrinsic types of atopic dermatitis
Background  Two types of atopic dermatitis (AD) have been proposed, with different pathophysiological mechanisms underlying this seemingly heterogeneous disorder. The extrinsic type shows high IgEExpand
Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging I: Reduced Skin Elasticity, Highly Associated with Enhanced Dermal Elastase Activity,
  • G. Imokawa, K. Ishida
  • Chemistry, Medicine
  • International journal of molecular sciences
  • 1 April 2015
Clinical studies using animal skin and human facial skin demonstrated that topical treatment with a specific inhibitor or an inhibitory extract of skin fibroblast-derived elastase distinctly attenuates UVB and sunlight-induced formation of wrinkling. Expand
Efficacy of the combined use of a facial cleanser and moisturizers for the care of mild acne patients with sensitive skin
The combined use of a facial skin cleanser and moisturizers is safe and effective for the care of acne in post‐adolescent Japanese women with sensitive skin. Expand
Role of Ceramide in the Barrier Function of the Stratum Corneum, Implications for the Pathogenesis of Atopic Dermatitis
This review article explores the physiological and biochemical basis for the atopic dermatitis phenotype in terms of the barrier abnormality and associated factors such as ceramides and its metabolites in the following sequence. Expand
Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging II: Over-Expression of Neprilysin Plays an Essential Role
Findings suggest that GM-CSF secreted by UVA-exposed keratinocytes as well as IL-6 secretedBy UVA -exposed dermal fibroblasts play important and additional roles in UVA/UVA-induced sagging and wrinkling by up-regulation of neprilysin and MMP-1, respectively, in dermal fibreblasts. Expand
Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile
The amelioration of lactic acid sensations by topical application of a ceramide complex cream provides a deep insight into the pathophysiology of sensitive skin as a reduced barrier function-dependent sub-clinical sensory response. Expand
Evaluation of a Barrier Repair Cream Containing Pseudo-Ceramide for Practical Use by Hairdressers with Hand Skin Disorders Due to Daily Exposure to Chemical Irritants
In this study, a controlled use test of a barrier repair cream containing pseudo-ceramide showed excellent skin compatibility and may be effective for hairdressers with dry, sensitive hands and/or occupational skin disorders. Expand
Efficacy and safety of pseudo-ceramide containing moisture cream in the treatment of senile xerosis
A pseudo-ceramide containing moisture cream was able to increase skin hydration and might be able to decrease trans-epidermal water loss in elderly patient with xerosis and improved some of the subjective symptoms of xerrosis, the clinical xerotic severity score and dermoscopic appearance. Expand
Treatment with Synthetic Pseudo-Ceramide Improves Atopic Skin Switching the Ceramide Profile to a Healthy Skin Phenotype.
Results indicate that the penetrated pCer contributes to shift the ceramide profile from an AD to a healthy skin phenotype, providing a deep insight into the pathogenesis of AD as a ceramide-deficient disease. Expand