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JBIR-56 and JBIR-57, 2(1H)-pyrazinones from a marine sponge-derived Streptomyces sp. SpD081030SC-03.
TLDR
Strain SpD081030SC-03, representing a novel species of Streptomyces, was isolated from a marine sponge and its structure was confirmed by the total synthesis of 1, which consists of a unique skeleton connected to the peptide chain at C-5 of the pyrazinone ring.
Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A.
TLDR
From the cytotoxic and spirocyclic natural product, spiromamakone A and its analogues, a more synthetically accessible spiroacetal template 4 was designed based on structural similarity analysis and appeared to act in a manner similar to the highly oxidized natural product.
Stereoselective Synthesis of Medium-sized Cyclic Compounds through the Intramolecular Michael-type Reaction Utilizing Alkyne-Hexacarbonyldicobalt Complex Formation
Alkyne–hexacarbonyldicobalt complexes having silyl enol ether and electron-deficient alkene moieties on opposite ends were treated with MeAlCl2 in the presence of 2,6-di-t-butylpyridine in CH2Cl2 t...