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A high signal-to-noise Ca2+ probe composed of a single green fluorescent protein
Recently, several groups have developed green fluorescent protein (GFP)-based Ca2+ probes. When applied in cells, however, these probes are difficult to use because of a low signal-to-noise ratio.Expand
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LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.
Redox status changes exert critical impacts on necrotic/apoptotic and normal cellular processes. We report here a widely expressed Ca2+-permeable cation channel, LTRPC2, activated by micromolarExpand
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Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
The structure–function relationship of the nicotinic acetylcholine receptor (AChR) has been effectively studied by the combination of complementary DNA manipulation and single-channel currentExpand
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Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
Distinct classes of acetylcholine receptor channels are formed when Xenopus oocytes are injected with combinations of the bovine α-, β-, γ- and δ- or the α-, β-, γ- and ε-subunit-specific messengerExpand
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Calcium channel characteristics conferred on the sodium channel by single mutations
THE sodium channel, one of the family of structurally homologous voltage-gated ion channels1, differs from other members, such as the calcium and the potassium channels, in its high selectivity forExpand
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Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel
IN cardiac muscle, where Ca2+ influx across the sarcolemma is essential for contraction, the dihydropyridine (DHP)-sensitive L-type calcium channel1 represents the major entry pathway ofExpand
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Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2.
Genetically encoded sensor proteins provide unique opportunities to advance the understanding of complex cellular interactions in physiologically relevant contexts; however, previously describedExpand
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Primary structure and functional expression from complementary DNA of a brain calcium channel
The primary structure of a voltage-dependent cal-cium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA isExpand
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Bidirectional Alterations in Cerebellar Synaptic Transmission oftottering and rollingCa2+ Channel Mutant Mice
Hereditary ataxic mice, tottering(tg) and rolling Nagoya (tgrol), carry mutations in the P/Q-type Ca2+ channel α1A subunit gene. The positions of the mutations and the neurological phenotypes areExpand
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A-Type K+ Current Mediated by the Kv4 Channel Regulates the Generation of Action Potential in Developing Cerebellar Granule Cells
During neuronal differentiation and maturation, electrical excitability is essential for proper gene expression and the formation of synapses. The expression of ion channels is crucial for thisExpand
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