Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique
- T. Harada, J. Katada, Y. Hayashi
- Chemistry
- 21 January 1997
Cytotoxic effects of NSL-1406, a new thienopyrimidine derivative, on leukocytes and osteoclasts.
- J. Katada, K. Iijima, Y. Hayashi
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 22 March 1999
Boronic-Acid-Catalyzed Regioselective and 1,2- cis-Stereoselective Glycosylation of Unprotected Sugar Acceptors via SNi-Type Mechanism.
- Masamichi Tanaka, A. Nakagawa, K. Toshima
- Chemistry, BiologyJournal of the American Chemical Society
- 19 February 2018
A highly regio- and 1,2- cis-stereoselective SNi-type glycosylation of 1, 2-anhydro donors and unprotected sugar acceptors using p-nitrophenylboronic acid (10e) as a catalyst under mild conditions is reported.
Stereospecific β-l-Rhamnopyranosylation through an SN i-Type Mechanism by Using Organoboron Reagents.
- Nobuya Nishi, Kazuhiro Sueoka, K. Iijima, R. Sawa, D. Takahashi, K. Toshima
- ChemistryAngewandte Chemie
- 15 October 2018
The present glycosylation method was applied successfully to the synthesis of a trisaccharide derived from Streptococcus pneumoniae serotypes 7B, 7C, and 7D and was consistent with a concerted SN i mechanism with an exploded transition state.
GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure.
- Y. Hayashi, J. Katada, I. Ojima
- Chemistry, BiologyJournal of Medicinal Chemistry
- 3 June 1998
The results suggest that 40 has an excellent therapeutic potential, especially for antithrombotic treatment in the acute phase, and 3-Substituted-2,2-dimethyl-beta-amino acid residues would serve as new and useful linear templates to restrict the conformational flexibility of peptidomimetics.
Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.
- Y. Hayashi, K. Iijima, J. Katada, Y. Kiso
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 7 February 2000
New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602
- H. Hashizume, S. Harada, M. Igarashi
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 14 August 2020
Two new dimeric cyclohexapeptides, chloptosins B and C, were discovered from the culture broth of Embleya sp. MM621-AF10 together with the known compounds chloptosin and L-156,602. The structures of…
Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors.
- K. Iijima, J. Katada, Y. Hayashi
- Chemistry, BiologyBioorganic & Medicinal Chemistry Letters
- 8 February 1999
Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4
- H. Hashizume, K. Iijima, M. Igarashi
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 15 November 2017
In the course of optimizing pargamicin A production in Amycolatopsis sp. ML1-hF4, we discovered novel cyclic depsipeptide compounds in the broth and designated them valgamicins A, C, T and V. The…
Stereospecific β‐ l ‐Rhamnopyranosylation through an S N i‐Type Mechanism by Using Organoboron Reagents
- Nobuya Nishi, Kazuhiro Sueoka, K. Iijima, R. Sawa, D. Takahashi, K. Toshima
- ChemistryAngewandte Chemie
- 19 September 2018
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