K. Hynynen

Publications662
h-index93
Citations30,576
Highly Influential Citations856
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Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits.
PURPOSE To determine if focused ultrasound beams can be used to locally open the blood-brain barrier without damage to surrounding brain tissue and if magnetic resonance (MR) imaging can be used to… Expand
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Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications
TLDR
The purpose of this study was to test the hypothesis that burst ultrasound in the presence of an ultrasound contrast agent can disrupt the blood-brain barrier (BBB) with acoustic parameters suitable for completely noninvasive exposure through the skull. Expand
  • 502
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MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study.
The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonications were delivered to nine targets.… Expand
  • 536
  • 18
  • PDF
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound
The clinical application of chemotherapy to brain tumors has been severely limited because antitumor agents are typically unable to penetrate an intact blood‐brain barrier (BBB). Although doxorubicin… Expand
  • 416
  • 17
Chemotherapy delivery issues in central nervous system malignancy: a reality check.
PURPOSE This review assesses the current state of knowledge regarding preclinical and clinical pharmacology for brain tumor chemotherapy and evaluates relevant brain tumor pharmacology studies before… Expand
  • 337
  • 17
  • PDF
The threshold for thermally significant cavitation in dog's thigh muscle in vivo.
  • K. Hynynen
  • Materials Science, Medicine
  • Ultrasound in medicine & biology
  • 1991
In this study the threshold of thermally significant transient cavitation in vivo in dog's thigh muscle was investigated as a function of frequency from 0.246 MHz to 1.68 MHz. Cavitation, evidenced… Expand
  • 393
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Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles.
Local blood-brain barrier (BBB) opening is an advantageous approach for targeted drug delivery to the brain. Recently, it has been shown that focused ultrasound (US) exposures (sonications), when… Expand
  • 385
  • 14
MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study.
PURPOSE To test the feasibility of noninvasive magnetic resonance (MR) imaging-guided focused ultrasound surgery (FUS) of benign fibroadenomas in the breast. MATERIALS AND METHODS Eleven… Expand
  • 604
  • 13
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium.
Previous studies have investigated a potential method for targeted drug delivery in the central nervous system that uses focused ultrasound bursts combined with an ultrasound contrast agent to… Expand
  • 280
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Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity.
Acoustic emission was monitored during focused ultrasound exposures in conjunction with an ultrasound contrast agent (Optison) in order to determine if cavitation activity is associated with the… Expand
  • 332
  • 11